Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4646257..4647089 Replicon chromosome
Accession NZ_CP069542
Organism Escherichia coli strain FDAARGOS_1248

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag I6J78_RS22330 Protein ID WP_000854753.1
Coordinates 4646257..4646631 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6J78_RS22335 Protein ID WP_204148142.1
Coordinates 4646721..4647089 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J78_RS22290 4641289..4642062 + 774 WP_000157137.1 type IV toxin-antitoxin system AbiEi family antitoxin -
I6J78_RS22295 4642055..4642972 + 918 WP_000361917.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
I6J78_RS22300 4643266..4643433 + 168 WP_001356018.1 hypothetical protein -
I6J78_RS22305 4643486..4644148 - 663 WP_000357928.1 hypothetical protein -
I6J78_RS22310 4644152..4644862 - 711 WP_001219054.1 integrase arm-type DNA-binding domain-containing protein -
I6J78_RS22315 4645326..4645478 - 153 WP_001280445.1 hypothetical protein -
I6J78_RS22320 4645563..4645760 - 198 WP_000839281.1 DUF957 domain-containing protein -
I6J78_RS22325 4645772..4646260 - 489 WP_000777547.1 hypothetical protein -
I6J78_RS22330 4646257..4646631 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
I6J78_RS22335 4646721..4647089 - 369 WP_204148142.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J78_RS22340 4647252..4647473 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6J78_RS22345 4647560..4648036 - 477 WP_001186725.1 RadC family protein -
I6J78_RS22350 4648052..4648537 - 486 WP_000849588.1 antirestriction protein -
I6J78_RS22355 4648592..4649413 - 822 WP_001234562.1 DUF945 domain-containing protein -
I6J78_RS22360 4649494..4649705 + 212 Protein_4354 hypothetical protein -
I6J78_RS22365 4649826..4650281 - 456 WP_000581498.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T190863 WP_000854753.1 NZ_CP069542:c4646631-4646257 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T190863 NZ_CP091563:3715145-3715672 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13490.24 Da        Isoelectric Point: 6.2050

>AT190863 WP_204148142.1 NZ_CP069542:c4647089-4646721 [Escherichia coli]
VLDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYSTPETKK

Download         Length: 369 bp

>AT190863 NZ_CP091563:3714858-3715148 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0


Antitoxin

Source ID Structure

References