Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4641289..4642972 Replicon chromosome
Accession NZ_CP069542
Organism Escherichia coli strain FDAARGOS_1248

Toxin (Protein)


Gene name mosT Uniprot ID I2UPR9
Locus tag I6J78_RS22295 Protein ID WP_000361917.1
Coordinates 4642055..4642972 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID I2UPX5
Locus tag I6J78_RS22290 Protein ID WP_000157137.1
Coordinates 4641289..4642062 (+) Length 258 a.a.

Genomic Context

I6J78_RS22275I6J78_RS22280I6J78_RS22290I6J78_RS22295I6J78_RS22300I6J78_RS22285I6J78_RS22305I6J78_RS22310I6J78_RS22315I6J78_RS22320I6J78_RS22325I6J78_RS22330I6J78_RS22335I6J78_RS22340
Location: 4637158..4639242 (2085 bp)
Type: Others
Protein ID: WP_050939399.1
Location: 4639361..4640710 (1350 bp)
Type: Others
Protein ID: WP_000766442.1
Location: 4641289..4642062 (774 bp)
Type: Antitoxin
Protein ID: WP_000157137.1
Location: 4642055..4642972 (918 bp)
Type: Toxin
Protein ID: WP_000361917.1
Location: 4643266..4643433 (168 bp)
Type: Others
Protein ID: WP_001356018.1
Location: 4640885..4641205 (321 bp)
Type: Others
Protein ID: Protein_4339
Location: 4643486..4644148 (663 bp)
Type: Others
Protein ID: WP_000357928.1
Location: 4644152..4644862 (711 bp)
Type: Others
Protein ID: WP_001219054.1
Location: 4645326..4645478 (153 bp)
Type: Others
Protein ID: WP_001280445.1
Location: 4645563..4645760 (198 bp)
Type: Others
Protein ID: WP_000839281.1
Location: 4645772..4646260 (489 bp)
Type: Others
Protein ID: WP_000777547.1
Location: 4646257..4646631 (375 bp)
Type: Others
Protein ID: WP_000854753.1
Location: 4646721..4647089 (369 bp)
Type: Others
Protein ID: WP_204148142.1
Location: 4647252..4647473 (222 bp)
Type: Others
Protein ID: WP_000692345.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6J78_RS222754637158..4639242+2085WP_050939399.1protease Lon-related BREX system protein BrxL-
I6J78_RS222804639361..4640710+1350WP_000766442.1phospholipase-
I6J78_RS222854640885..4641205-321Protein_4339IS3 family transposase-
I6J78_RS222904641289..4642062+774WP_000157137.1type IV toxin-antitoxin system AbiEi family antitoxinAntitoxin
I6J78_RS222954642055..4642972+918WP_000361917.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
I6J78_RS223004643266..4643433+168WP_001356018.1hypothetical protein-
I6J78_RS223054643486..4644148-663WP_000357928.1hypothetical protein-
I6J78_RS223104644152..4644862-711WP_001219054.1integrase arm-type DNA-binding domain-containing protein-
I6J78_RS223154645326..4645478-153WP_001280445.1hypothetical protein-
I6J78_RS223204645563..4645760-198WP_000839281.1DUF957 domain-containing protein-
I6J78_RS223254645772..4646260-489WP_000777547.1hypothetical protein-
I6J78_RS223304646257..4646631-375WP_000854753.1TA system toxin CbtA family protein-
I6J78_RS223354646721..4647089-369WP_204148142.1type IV toxin-antitoxin system YeeU family antitoxin-
I6J78_RS223404647252..4647473-222WP_000692345.1DUF987 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34963.04 Da        Isoelectric Point: 4.7716

>T190862 WP_000361917.1 NZ_CP069542:4642055-4642972 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIVYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTEWLR

Download         Length: 918 bp

>T190862 NZ_CP091563:c2631330-2631227 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 29333.76 Da        Isoelectric Point: 9.9889

>AT190862 WP_000157137.1 NZ_CP069542:4641289-4642062 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPAVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Download         Length: 774 bp

>AT190862 NZ_CP091563:2631225-2631370 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H0PS08

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H0N3W2

References