Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4589659..4590235 Replicon chromosome
Accession NZ_CP069542
Organism Escherichia coli strain FDAARGOS_1248

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag I6J78_RS22070 Protein ID WP_001297643.1
Coordinates 4589948..4590235 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag I6J78_RS22065 Protein ID WP_000063160.1
Coordinates 4589659..4589961 (-) Length 101 a.a.

Genomic Context

I6J78_RS22050I6J78_RS22055I6J78_RS22060I6J78_RS22080I6J78_RS22085I6J78_RS22065I6J78_RS22070I6J78_RS22075
Location: 4586255..4588405 (2151 bp)
Type: Others
Protein ID: WP_001340937.1
Location: 4588455..4588658 (204 bp)
Type: Others
Protein ID: WP_000467859.1
Location: 4588669..4589625 (957 bp)
Type: Others
Protein ID: WP_001297640.1
Location: 4591445..4592677 (1233 bp)
Type: Others
Protein ID: WP_001137031.1
Location: 4592718..4593998 (1281 bp)
Type: Others
Protein ID: WP_001037390.1
Location: 4589659..4589961 (303 bp)
Type: Antitoxin
Protein ID: WP_000063160.1
Location: 4589948..4590235 (288 bp)
Type: Toxin
Protein ID: WP_001297643.1
Location: 4590434..4591130 (697 bp)
Type: Others
Protein ID: Protein_4297
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6J78_RS220504586255..4588405+2151WP_001340937.1pyruvate/proton symporter BtsT-
I6J78_RS220554588455..4588658+204WP_000467859.1YbdD/YjiX family protein-
I6J78_RS220604588669..4589625+957WP_001297640.1GTPase-
I6J78_RS220654589659..4589961-303WP_000063160.1BrnA antitoxin family proteinAntitoxin
I6J78_RS220704589948..4590235-288WP_001297643.1BrnT family toxinToxin
I6J78_RS220754590434..4591130-697Protein_4297IS1 family transposase-
I6J78_RS220804591445..4592677+1233WP_001137031.1multidrug efflux MFS transporter MdtM-
I6J78_RS220854592718..4593998+1281WP_001037390.1DUF445 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--4590434..4590643209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T190861 WP_001297643.1 NZ_CP069542:c4590235-4589948 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T190861 NZ_CP091563:c2290006-2289722 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT190861 WP_000063160.1 NZ_CP069542:c4589961-4589659 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT190861 NZ_CP091563:c2290244-2289996 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829GEV9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A080I7H7

References