Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2808806..2809332 Replicon chromosome
Accession NZ_CP069542
Organism Escherichia coli strain FDAARGOS_1248

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6J78_RS13310 Protein ID WP_000323025.1
Coordinates 2809045..2809332 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag I6J78_RS13305 Protein ID WP_000534858.1
Coordinates 2808806..2809045 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J78_RS13275 2803920..2804171 + 252 Protein_2577 DUF977 family protein -
I6J78_RS13280 2804168..2804524 + 357 WP_204148116.1 class I SAM-dependent methyltransferase -
I6J78_RS13285 2805135..2805422 + 288 Protein_2579 hypothetical protein -
I6J78_RS13290 2806191..2807504 + 1314 WP_000589005.1 ISNCY family transposase -
I6J78_RS13295 2807941..2808273 - 333 WP_001301033.1 protein FlxA -
I6J78_RS13300 2808476..2808781 - 306 WP_001326990.1 hypothetical protein -
I6J78_RS13305 2808806..2809045 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6J78_RS13310 2809045..2809332 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6J78_RS13315 2809404..2809559 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
I6J78_RS13320 2809776..2810027 + 252 WP_000980994.1 hypothetical protein -
I6J78_RS13325 2810094..2810372 + 279 WP_012304870.1 hypothetical protein -
I6J78_RS13330 2810374..2811423 + 1050 WP_001265198.1 DUF968 domain-containing protein -
I6J78_RS13335 2811437..2812189 + 753 WP_001047135.1 antitermination protein -
I6J78_RS13340 2812496..2812654 - 159 Protein_2590 cold shock-like protein CspF -
I6J78_RS13345 2812955..2813170 + 216 WP_000066484.1 cold shock-like protein CspB -
I6J78_RS13350 2813924..2814139 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2797819..2830026 32207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T190854 WP_000323025.1 NZ_CP069542:2809045-2809332 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T190854 NZ_CP091560:4792845-4793156 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT190854 WP_000534858.1 NZ_CP069542:2808806-2809045 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT190854 NZ_CP091560:4793153-4793599 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References