Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2314513..2315344 Replicon chromosome
Accession NZ_CP069542
Organism Escherichia coli strain FDAARGOS_1248

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6J78_RS10840 Protein ID WP_000854814.1
Coordinates 2314513..2314887 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag I6J78_RS10845 Protein ID WP_001285585.1
Coordinates 2314976..2315344 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J78_RS10800 2309909..2311075 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6J78_RS10805 2311194..2311667 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
I6J78_RS10810 2311865..2312923 + 1059 WP_158137946.1 FUSC family protein -
I6J78_RS10815 2313095..2313424 + 330 WP_000450409.1 DUF496 family protein -
I6J78_RS10820 2313525..2313707 - 183 WP_001016348.1 hypothetical protein -
I6J78_RS10825 2313779..2313907 + 129 Protein_2098 transposase domain-containing protein -
I6J78_RS10830 2314196..2314309 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J78_RS10835 2314322..2314516 - 195 WP_000988600.1 hypothetical protein -
I6J78_RS10840 2314513..2314887 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J78_RS10845 2314976..2315344 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J78_RS10850 2315418..2315639 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6J78_RS10855 2315702..2316178 - 477 WP_001186773.1 RadC family protein -
I6J78_RS10860 2316194..2316673 - 480 WP_000860076.1 antirestriction protein -
I6J78_RS10865 2316755..2317576 - 822 WP_001234530.1 DUF945 domain-containing protein -
I6J78_RS10870 2317797..2318207 - 411 WP_000846713.1 hypothetical protein -
I6J78_RS10875 2318223..2318690 - 468 WP_158137953.1 hypothetical protein -
I6J78_RS10880 2318683..2319380 - 698 Protein_2109 IS1 family transposase -
I6J78_RS10885 2319438..2319683 - 246 Protein_2110 hypothetical protein -
I6J78_RS10890 2319819..2320196 - 378 WP_001453941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T190845 WP_000854814.1 NZ_CP069542:c2314887-2314513 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190845 NZ_CP091560:c1026858-1026331 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT190845 WP_001285585.1 NZ_CP069542:c2315344-2314976 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190845 NZ_CP091560:c1027145-1026855 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References