Detailed information of TA system TA190842

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1218983..1219818
• Replicon: chromosome
• Accession: NZ_CP069542
• Organism: Escherichia coli strain FDAARGOS_1248

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6J78_RS05725
• Protein ID: WP_089614471.1
• Coordinates: 1218983..1219360 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7W3AJG7
• Locus tag: I6J78_RS05730
• Protein ID: WP_001389198.1
• Coordinates: 1219450..1219818 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J78_RS05700	1215098..1216543	+	1446	WP_000933249.1	inorganic phosphate transporter PitB	-
I6J78_RS05705	1216545..1217081	+	537	WP_000942785.1	GspM family type II secretion system protein YghD	-
I6J78_RS05710	1217362..1218204	-	843	WP_001290191.1	DUF4942 domain-containing protein	-
I6J78_RS05715	1218289..1218486	-	198	WP_000839291.1	DUF957 domain-containing protein	-
I6J78_RS05720	1218498..1218986	-	489	WP_000761678.1	hypothetical protein	-
I6J78_RS05725	1218983..1219360	-	378	WP_089614471.1	TA system toxin CbtA family protein	Toxin
I6J78_RS05730	1219450..1219818	-	369	WP_001389198.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J78_RS05735	1219898..1220119	-	222	WP_000692287.1	DUF987 domain-containing protein	-
I6J78_RS05740	1220206..1220682	-	477	WP_001186744.1	RadC family protein	-
I6J78_RS05745	1220698..1221183	-	486	WP_000213717.1	antirestriction protein	-
I6J78_RS05750	1221260..1222078	-	819	WP_001175170.1	DUF945 domain-containing protein	-
I6J78_RS05755	1222168..1222401	-	234	WP_001278288.1	DUF905 family protein	-
I6J78_RS05760	1222407..1223084	-	678	WP_001097362.1	hypothetical protein	-
I6J78_RS05765	1223203..1224087	-	885	WP_000010399.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14079.17 Da
• Isoelectric Point: 8.2830

>T190842 WP_089614471.1 NZ_CP069542:c1219360-1218983 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T190842 NZ_CP091560:365061-365336 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13610.39 Da
• Isoelectric Point: 6.3159

>AT190842 WP_001389198.1 NZ_CP069542:c1219818-1219450 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT190842 NZ_CP091560:364798-365058 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W3AJG7