Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 20725..21253 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP069540 | ||
| Organism | Acinetobacter pittii strain FDAARGOS_1214 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B0V430 |
| Locus tag | I6J44_RS19265 | Protein ID | WP_000221360.1 |
| Coordinates | 20960..21253 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B0V429 |
| Locus tag | I6J44_RS19260 | Protein ID | WP_000246757.1 |
| Coordinates | 20725..20970 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J44_RS19230 | 16127..17125 | + | 999 | WP_002120211.1 | zinc-binding alcohol dehydrogenase family protein | - |
| I6J44_RS19235 | 17146..17430 | + | 285 | WP_000155817.1 | antibiotic biosynthesis monooxygenase | - |
| I6J44_RS19240 | 17565..17786 | + | 222 | Protein_19 | IS3 family transposase | - |
| I6J44_RS19245 | 18196..18714 | + | 519 | WP_000447196.1 | sel1 repeat family protein | - |
| I6J44_RS19250 | 18846..19358 | + | 513 | WP_001089570.1 | SMI1/KNR4 family protein | - |
| I6J44_RS19255 | 19566..20468 | + | 903 | WP_000466974.1 | hypothetical protein | - |
| I6J44_RS19260 | 20725..20970 | + | 246 | WP_000246757.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I6J44_RS19265 | 20960..21253 | + | 294 | WP_000221360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6J44_RS19270 | 21440..21556 | + | 117 | Protein_25 | transposase | - |
| I6J44_RS19275 | 22571..22879 | + | 309 | WP_000269910.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6J44_RS19280 | 22920..23222 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | - |
| I6J44_RS19285 | 23215..23424 | + | 210 | WP_000069470.1 | hypothetical protein | - |
| I6J44_RS19290 | 23534..23761 | - | 228 | WP_000555567.1 | hypothetical protein | - |
| I6J44_RS19295 | 24527..24830 | - | 304 | Protein_30 | helix-turn-helix transcriptional regulator | - |
| I6J44_RS19300 | 24823..25179 | - | 357 | WP_000269908.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..94387 | 94387 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11317.49 Da Isoelectric Point: 10.4753
>T190837 WP_000221360.1 NZ_CP069540:20960-21253 [Acinetobacter pittii]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T190837 NZ_CP091558:c4974089-4973778 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9264.63 Da Isoelectric Point: 4.2821
>AT190837 WP_000246757.1 NZ_CP069540:20725-20970 [Acinetobacter pittii]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
Download Length: 246 bp
>AT190837 NZ_CP091558:c4973781-4973335 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829RR87 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A009MZ79 |