Detailed information of TA system TA190836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 3291..3840
• Replicon: plasmid unnamed1
• Accession: NZ_CP069538
• Organism: Acinetobacter pittii strain FDAARGOS_1214

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9KJ78
• Locus tag: I6J44_RS19095
• Protein ID: WP_000176412.1
• Coordinates: 3550..3840 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9KCM7
• Locus tag: I6J44_RS19090
• Protein ID: WP_005140357.1
• Coordinates: 3291..3566 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J44_RS19065	139..915	+	777	WP_000191151.1	hypothetical protein	-
I6J44_RS19070	1140..2339	+	1200	WP_002072939.1	hypothetical protein	-
I6J44_RS19075	2412..2654	-	243	WP_001015364.1	hypothetical protein	-
I6J44_RS19080	2803..3027	+	225	WP_002072934.1	hypothetical protein	-
I6J44_RS19085	3131..3286	+	156	WP_158000192.1	hypothetical protein	-
I6J44_RS19090	3291..3566	+	276	WP_005140357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6J44_RS19095	3550..3840	+	291	WP_000176412.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I6J44_RS19100	3888..4034	-	147	WP_000192351.1	hypothetical protein	-
I6J44_RS19105	4031..4552	-	522	WP_000999915.1	hypothetical protein	-
I6J44_RS19110	5077..5394	-	318	WP_005065053.1	hypothetical protein	-
I6J44_RS19115	5745..6311	-	567	WP_000858429.1	plasmid replication DNA-binding protein	-
I6J44_RS19120	6375..7256	-	882	WP_005804946.1	replication initiation protein RepM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9132	9132

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (9-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11187.12 Da
• Isoelectric Point: 6.9783

>T190836 WP_000176412.1 NZ_CP069538:3550-3840 [Acinetobacter pittii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Nucleotide

• Length: 291 bp

>T190836 NZ_CP091558:c4570758-4570273 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10290.65 Da
• Isoelectric Point: 4.6702

>AT190836 WP_005140357.1 NZ_CP069538:3291-3566 [Acinetobacter pittii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Nucleotide

• Length: 276 bp

>AT190836 NZ_CP091558:c4571033-4570746 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: N9KJ78

Antitoxin

• AlphaFold DB: N9KCM7