Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 75558..75988 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP069530 | ||
| Organism | Escherichia coli strain FDAARGOS_1252 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | I6J82_RS25735 | Protein ID | WP_001388374.1 |
| Coordinates | 75558..75722 (-) | Length | 55 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6Y0EDY2 |
| Locus tag | I6J82_RS25740 | Protein ID | WP_000079939.1 |
| Coordinates | 75719..75988 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J82_RS25705 | 70627..71442 | + | 816 | WP_001043260.1 | sulfonamide-resistant dihydropteroate synthase Sul2 | - |
| I6J82_RS25710 | 71503..72306 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| I6J82_RS25715 | 72306..73142 | + | 837 | WP_000480972.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| I6J82_RS25720 | 73249..73653 | - | 405 | Protein_74 | IS91 family transposase | - |
| I6J82_RS25725 | 73765..74145 | - | 381 | WP_001696636.1 | HTH domain-containing protein | - |
| I6J82_RS25730 | 74587..75510 | - | 924 | WP_001415483.1 | hypothetical protein | - |
| I6J82_RS25735 | 75558..75722 | - | 165 | WP_001388374.1 | hypothetical protein | Toxin |
| I6J82_RS25740 | 75719..75988 | - | 270 | WP_000079939.1 | hypothetical protein | Antitoxin |
| I6J82_RS25745 | 76061..76201 | - | 141 | WP_021503378.1 | hypothetical protein | - |
| I6J82_RS25750 | 76902..77759 | - | 858 | WP_032251529.1 | incFII family plasmid replication initiator RepA | - |
| I6J82_RS25755 | 77752..77826 | - | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
| I6J82_RS25760 | 78071..78319 | - | 249 | WP_000083839.1 | replication regulatory protein RepA | - |
| I6J82_RS25765 | 78559..79149 | - | 591 | WP_000766807.1 | DUF2726 domain-containing protein | - |
| I6J82_RS25770 | 79187..79396 | - | 210 | WP_001333231.1 | hemolysin expression modulator Hha | - |
| I6J82_RS25775 | 79442..79903 | - | 462 | WP_000978819.1 | thermonuclease family protein | - |
| I6J82_RS25780 | 80148..80360 | - | 213 | WP_001301409.1 | ANR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 / aph(3'')-Ib / aph(6)-Id | senB / iroN / iroE / iroD / iroC / iroB | 1..96693 | 96693 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 55 a.a. Molecular weight: 6604.73 Da Isoelectric Point: 7.1989
>T190833 WP_001388374.1 NZ_CP069530:c75722-75558 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYFGRTHRLTPVLHLYYM
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYFGRTHRLTPVLHLYYM
Download Length: 165 bp
>T190833 NZ_CP091558:c3869184-3868657 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10233.54 Da Isoelectric Point: 6.7263
>AT190833 WP_000079939.1 NZ_CP069530:c75988-75719 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT190833 NZ_CP091558:c3869471-3869181 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|