Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3677107..3677941 Replicon chromosome
Accession NZ_CP069528
Organism Escherichia coli strain FDAARGOS_1252

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag I6J82_RS17670 Protein ID WP_000854689.1
Coordinates 3677564..3677941 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6J82_RS17665 Protein ID WP_001545732.1
Coordinates 3677107..3677487 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J82_RS17630 3673116..3673571 + 456 WP_021528086.1 hypothetical protein -
I6J82_RS17635 3673672..3673803 + 132 WP_106108514.1 DUF905 family protein -
I6J82_RS17640 3673982..3674803 + 822 WP_021528087.1 DUF945 domain-containing protein -
I6J82_RS17645 3675145..3675618 + 474 WP_001387789.1 antirestriction protein -
I6J82_RS17650 3675634..3676110 + 477 WP_001186727.1 RadC family protein -
I6J82_RS17655 3676173..3676394 + 222 WP_000692330.1 DUF987 domain-containing protein -
I6J82_RS17660 3676413..3677057 + 645 WP_001545733.1 hypothetical protein -
I6J82_RS17665 3677107..3677487 + 381 WP_001545732.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J82_RS17670 3677564..3677941 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
I6J82_RS17675 3677938..3678426 + 489 WP_000761698.1 hypothetical protein -
I6J82_RS17680 3678443..3678631 + 189 WP_096972724.1 DUF957 domain-containing protein -
I6J82_RS17685 3678745..3679563 + 819 WP_001545729.1 DUF4942 domain-containing protein -
I6J82_RS17690 3679622..3679825 - 204 WP_001545728.1 hypothetical protein -
I6J82_RS17695 3679835..3680485 - 651 WP_000056760.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
I6J82_RS17700 3680499..3680963 - 465 WP_000776510.1 PTS ascorbate transporter subunit IIA -
I6J82_RS17705 3680973..3681278 - 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
I6J82_RS17710 3681294..3682691 - 1398 WP_001540536.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T190817 WP_000854689.1 NZ_CP069528:3677564-3677941 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T190817 NZ_CP091556:3636563-3636838 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13994.73 Da        Isoelectric Point: 5.0696

>AT190817 WP_001545732.1 NZ_CP069528:3677107-3677487 [Escherichia coli]
VSDTLSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT190817 NZ_CP091556:c3636828-3636406 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References