Detailed information of TA system TA190805

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2512853..2513657
• Replicon: chromosome
• Accession: NZ_CP069528
• Organism: Escherichia coli strain FDAARGOS_1252

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6J82_RS12100
• Protein ID: WP_115766378.1
• Coordinates: 2513277..2513657 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MN76
• Locus tag: I6J82_RS12095
• Protein ID: WP_015953067.1
• Coordinates: 2512853..2513230 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J82_RS12060	2508771..2509451	+	681	WP_001282919.1	WYL domain-containing protein	-
I6J82_RS12065	2509599..2510276	+	678	WP_001097307.1	hypothetical protein	-
I6J82_RS12070	2510282..2510515	+	234	WP_001278280.1	DUF905 family protein	-
I6J82_RS12075	2510605..2511423	+	819	WP_077532164.1	DUF945 domain-containing protein	-
I6J82_RS12080	2511514..2511999	+	486	WP_021522473.1	antirestriction protein	-
I6J82_RS12085	2512014..2512490	+	477	WP_001186726.1	RadC family protein	-
I6J82_RS12090	2512553..2512774	+	222	WP_000692329.1	DUF987 domain-containing protein	-
I6J82_RS12095	2512853..2513230	+	378	WP_015953067.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
I6J82_RS12100	2513277..2513657	+	381	WP_115766378.1	TA system toxin CbtA family protein	Toxin
I6J82_RS12105	2513879..2514076	+	198	WP_023563519.1	DUF957 domain-containing protein	-
I6J82_RS12110	2514161..2515009	+	849	WP_001280489.1	DUF4942 domain-containing protein	-
I6J82_RS12115	2515165..2516664	+	1500	WP_000174399.1	IS21-like element ISEc10 family transposase	-
I6J82_RS12120	2516661..2517416	+	756	WP_000065240.1	IS21-like element ISEc10 family helper ATPase IstB	-
I6J82_RS12125	2517729..2518388	+	660	WP_001159065.1	glutamine ABC transporter permease GlnP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14072.88 Da
• Isoelectric Point: 5.5666

>T190805 WP_115766378.1 NZ_CP069528:2513277-2513657 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Nucleotide

• Length: 381 bp

>T190805 NZ_CP091554:c4940104-4939793 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13766.60 Da
• Isoelectric Point: 6.2021

>AT190805 WP_015953067.1 NZ_CP069528:2512853-2513230 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Nucleotide

• Length: 378 bp

>AT190805 NZ_CP091554:c4939796-4939350 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A5Z3CIS0