Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1042038..1042869 Replicon chromosome
Accession NZ_CP069528
Organism Escherichia coli strain FDAARGOS_1252

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6J82_RS04770 Protein ID WP_000854814.1
Coordinates 1042038..1042412 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6J82_RS04775 Protein ID WP_001285586.1
Coordinates 1042501..1042869 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J82_RS04730 1037435..1038601 + 1167 WP_033548239.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6J82_RS04735 1038720..1039193 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6J82_RS04740 1039391..1040449 + 1059 WP_001200890.1 FUSC family protein -
I6J82_RS04745 1040621..1040950 + 330 WP_000450409.1 DUF496 family protein -
I6J82_RS04750 1041050..1041232 - 183 WP_033548241.1 ethanolamine utilization protein -
I6J82_RS04755 1041286..1041432 + 147 Protein_926 transposase domain-containing protein -
I6J82_RS04760 1041721..1041834 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J82_RS04765 1041847..1042041 - 195 WP_000988601.1 hypothetical protein -
I6J82_RS04770 1042038..1042412 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J82_RS04775 1042501..1042869 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J82_RS04780 1042943..1043164 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6J82_RS04785 1043233..1043709 - 477 WP_021531870.1 RadC family protein -
I6J82_RS04790 1043725..1044198 - 474 WP_001537423.1 antirestriction protein -
I6J82_RS04795 1044461..1045282 - 822 WP_001234571.1 DUF945 domain-containing protein -
I6J82_RS04800 1045503..1045913 - 411 WP_000846704.1 hypothetical protein -
I6J82_RS04805 1045929..1046606 - 678 WP_001362823.1 hypothetical protein -
I6J82_RS04810 1046742..1047812 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T190795 WP_000854814.1 NZ_CP069528:c1042412-1042038 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190795 NZ_CP091554:c954500-954225 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT190795 WP_001285586.1 NZ_CP069528:c1042869-1042501 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190795 NZ_CP091554:954235-954657 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References