Detailed information of TA system TA190786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4863488..4864476
• Replicon: chromosome
• Accession: NZ_CP069522
• Organism: Escherichia coli strain FDAARGOS_1267

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: I6J97_RS23625
• Protein ID: WP_014640052.1
• Coordinates: 4863488..4863874 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: I6J97_RS23630
• Protein ID: WP_000458584.1
• Coordinates: 4863904..4864476 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J97_RS23575	4858571..4859395	+	825	WP_000081295.1	YfdQ family protein	-
I6J97_RS23580	4859524..4860060	+	537	WP_000008178.1	5'-deoxynucleotidase	-
I6J97_RS23585	4860051..4860470	+	420	WP_021549915.1	hypothetical protein	-
I6J97_RS23590	4860467..4860766	+	300	WP_021549914.1	hypothetical protein	-
I6J97_RS23595	4860768..4861448	+	681	WP_021549913.1	ead/Ea22-like family protein	-
I6J97_RS23600	4861450..4861737	+	288	WP_021549912.1	hypothetical protein	-
I6J97_RS23605	4861741..4862337	+	597	WP_021549911.1	DUF551 domain-containing protein	-
I6J97_RS23610	4862337..4862909	+	573	WP_021549910.1	3'-5' exoribonuclease	-
I6J97_RS23615	4862946..4863227	+	282	WP_001093919.1	pyocin activator PrtN family protein	-
I6J97_RS23620	4863275..4863448	-	174	WP_021549909.1	hypothetical protein	-
I6J97_RS23625	4863488..4863874	-	387	WP_014640052.1	hypothetical protein	Toxin
I6J97_RS23630	4863904..4864476	-	573	WP_000458584.1	SocA family protein	Antitoxin
I6J97_RS23635	4864948..4865463	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
I6J97_RS23640	4865505..4865714	-	210	WP_001296638.1	CsbD family protein	-
I6J97_RS23645	4865830..4867155	-	1326	WP_001350407.1	MATE family efflux transporter DinF	-
I6J97_RS23650	4867228..4867836	-	609	WP_000646078.1	transcriptional repressor LexA	-
I6J97_RS23655	4867946..4868314	-	369	WP_000002907.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4814735..4876485	61750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T190786 WP_014640052.1 NZ_CP069522:c4863874-4863488 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T190786 NZ_CP091547:c4426900-4426625 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT190786 WP_000458584.1 NZ_CP069522:c4864476-4863904 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT190786 NZ_CP091547:c4427163-4426903 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5