Detailed information of TA system TA190783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4358345..4359165
• Replicon: chromosome
• Accession: NZ_CP069522
• Organism: Escherichia coli strain FDAARGOS_1267

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6J97_RS21080
• Protein ID: WP_001054376.1
• Coordinates: 4358345..4358602 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J97_RS21085
• Protein ID: WP_001519303.1
• Coordinates: 4358614..4359165 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J97_RS21060	4353631..4354737	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
I6J97_RS21065	4354802..4355782	+	981	WP_001519307.1	transposase	-
I6J97_RS21070	4356365..4357606	-	1242	Protein_4132	DNA helicase	-
I6J97_RS21075	4357669..4357968	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
I6J97_RS21080	4358345..4358602	+	258	WP_001054376.1	hypothetical protein	Toxin
I6J97_RS21085	4358614..4359165	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
I6J97_RS21090	4359217..4359378	+	162	WP_001519302.1	hypothetical protein	-
I6J97_RS21095	4359415..4359963	+	549	WP_001519301.1	hypothetical protein	-
I6J97_RS21100	4360090..4360350	+	261	WP_000084876.1	hypothetical protein	-
I6J97_RS21105	4360388..4360504	+	117	Protein_4139	VOC family protein	-
I6J97_RS21110	4360749..4361870	+	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J97_RS21115	4361867..4362145	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J97_RS21120	4362157..4363470	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	4347360..4359378	12018

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T190783 WP_001054376.1 NZ_CP069522:4358345-4358602 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190783 NZ_CP091547:3714664-3715191 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT190783 WP_001519303.1 NZ_CP069522:4358614-4359165 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190783 NZ_CP091547:3714377-3714667 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: S1PA82