Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4153763..4154313 Replicon chromosome
Accession NZ_CP069522
Organism Escherichia coli strain FDAARGOS_1267

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag I6J97_RS20015 Protein ID WP_001160966.1
Coordinates 4153763..4154077 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag I6J97_RS20020 Protein ID WP_000125566.1
Coordinates 4154080..4154313 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J97_RS19990 4149438..4150724 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
I6J97_RS19995 4150724..4151713 + 990 WP_000241228.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
I6J97_RS20000 4151710..4152531 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I6J97_RS20005 4152534..4152911 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
I6J97_RS20010 4152918..4153766 + 849 WP_000257182.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
I6J97_RS20015 4153763..4154077 - 315 WP_001160966.1 CcdB family protein Toxin
I6J97_RS20020 4154080..4154313 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6J97_RS20025 4154399..4154878 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
I6J97_RS20030 4155070..4156932 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
I6J97_RS20035 4156925..4157455 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
I6J97_RS20040 4157563..4158894 - 1332 WP_001183207.1 MFS transporter -
I6J97_RS20045 4158953..4159240 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T190779 WP_001160966.1 NZ_CP069522:c4154077-4153763 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T190779 NZ_CP091547:c994935-994660 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT190779 WP_000125566.1 NZ_CP069522:c4154313-4154080 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT190779 NZ_CP091547:994670-995092 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References