Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1871126..1871957 Replicon chromosome
Accession NZ_CP069522
Organism Escherichia coli strain FDAARGOS_1267

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6J97_RS08815 Protein ID WP_000854814.1
Coordinates 1871126..1871500 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag I6J97_RS08820 Protein ID WP_001518724.1
Coordinates 1871589..1871957 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J97_RS08775 1866522..1867688 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6J97_RS08780 1867807..1868280 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6J97_RS08785 1868478..1869536 + 1059 WP_001200894.1 FUSC family protein -
I6J97_RS08790 1869708..1870037 + 330 WP_000450409.1 DUF496 family protein -
I6J97_RS08795 1870138..1870320 - 183 WP_001016348.1 hypothetical protein -
I6J97_RS08800 1870374..1870520 + 147 Protein_1723 transposase domain-containing protein -
I6J97_RS08805 1870809..1870922 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J97_RS08810 1870935..1871129 - 195 WP_000988601.1 hypothetical protein -
I6J97_RS08815 1871126..1871500 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J97_RS08820 1871589..1871957 - 369 WP_001518724.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J97_RS08825 1872031..1872252 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6J97_RS08830 1872315..1872791 - 477 WP_001186773.1 RadC family protein -
I6J97_RS08835 1872807..1873280 - 474 WP_000855075.1 antirestriction protein -
I6J97_RS08840 1873543..1874364 - 822 WP_001234710.1 DUF945 domain-containing protein -
I6J97_RS08845 1874585..1874995 - 411 WP_000846705.1 hypothetical protein -
I6J97_RS08850 1875011..1875664 - 654 WP_001518719.1 hypothetical protein -
I6J97_RS08855 1875757..1876934 + 1178 WP_152895938.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T190766 WP_000854814.1 NZ_CP069522:c1871500-1871126 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190766 NZ_CP091544:2185770-2185873 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT190766 WP_001518724.1 NZ_CP069522:c1871957-1871589 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190766 NZ_CP091544:c2185875-2185730 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References