Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 757413..758245 Replicon chromosome
Accession NZ_CP069522
Organism Escherichia coli strain FDAARGOS_1267

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag I6J97_RS03740 Protein ID WP_000854753.1
Coordinates 757413..757787 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag I6J97_RS03745 Protein ID WP_001278232.1
Coordinates 757877..758245 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J97_RS03710 752527..753675 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
I6J97_RS03715 753747..754730 - 984 WP_001331698.1 KpsF/GutQ family sugar-phosphate isomerase -
I6J97_RS03720 755541..755711 - 171 Protein_731 IS110 family transposase -
I6J97_RS03725 756053..756622 - 570 WP_001290241.1 DUF4942 domain-containing protein -
I6J97_RS03730 756719..756916 - 198 WP_000839281.1 DUF957 domain-containing protein -
I6J97_RS03735 756928..757416 - 489 WP_000777541.1 hypothetical protein -
I6J97_RS03740 757413..757787 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
I6J97_RS03745 757877..758245 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J97_RS03750 758408..758629 - 222 WP_000692316.1 DUF987 domain-containing protein -
I6J97_RS03755 758692..759168 - 477 WP_001186726.1 RadC family protein -
I6J97_RS03760 759184..759669 - 486 WP_001520165.1 antirestriction protein -
I6J97_RS03765 759724..760542 - 819 WP_001520163.1 DUF945 domain-containing protein -
I6J97_RS03770 760642..760875 - 234 WP_001119729.1 DUF905 family protein -
I6J97_RS03775 760954..761409 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T190762 WP_000854753.1 NZ_CP069522:c757787-757413 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T190762 NZ_CP091544:365838-366113 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT190762 WP_001278232.1 NZ_CP069522:c758245-757877 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT190762 NZ_CP091544:365575-365835 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References