Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 7747..8293 Replicon plasmid unnamed
Accession NZ_CP069521
Organism Enterocloster bolteae strain FDAARGOS_1231

Toxin (Protein)


Gene name relE Uniprot ID A8S0R9
Locus tag I6J61_RS30300 Protein ID WP_007038024.1
Coordinates 8015..8293 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A414AJ69
Locus tag I6J61_RS30295 Protein ID WP_007038025.1
Coordinates 7747..8022 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J61_RS30260 3792..4589 - 798 WP_007038033.1 hypothetical protein -
I6J61_RS30265 4701..4958 - 258 WP_007038032.1 hypothetical protein -
I6J61_RS30270 5015..5359 - 345 WP_007038031.1 hypothetical protein -
I6J61_RS30275 5390..5641 - 252 WP_007038030.1 hypothetical protein -
I6J61_RS30280 6046..6789 - 744 WP_039897592.1 AAA family ATPase -
I6J61_RS30285 6863..7075 - 213 WP_007038027.1 hypothetical protein -
I6J61_RS30290 7059..7316 - 258 WP_007038026.1 hypothetical protein -
I6J61_RS30295 7747..8022 + 276 WP_007038025.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J61_RS30300 8015..8293 + 279 WP_007038024.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6J61_RS30305 8443..8778 - 336 WP_039897591.1 hypothetical protein -
I6J61_RS30310 8915..9214 + 300 WP_039897589.1 helix-turn-helix domain-containing protein -
I6J61_RS30315 10449..11285 - 837 WP_007038019.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43772 43772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10942.65 Da        Isoelectric Point: 8.4737

>T190760 WP_007038024.1 NZ_CP069521:8015-8293 [Enterocloster bolteae]
MLKIEYQGQFKKDYKLALKRGCNPELLTEVISMLANEQELPEKYRDHNLMNSRSYKNARECHIQPDWLLIYQTNKDILTL
KLLRTGSHSDLF

Download         Length: 279 bp

>T190760 NZ_CP091544:207582-208067 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10209.60 Da        Isoelectric Point: 4.5388

>AT190760 WP_007038025.1 NZ_CP069521:7747-8022 [Enterocloster bolteae]
MSEKNTSMNIRMNKDVKLQAQKVFSDLGIDLTTAVNVFLRQSIRYQGFPFDVTLRQEPNATTMAAIENADKGIDMHGPFE
SVEALMEDLNA

Download         Length: 276 bp

>AT190760 NZ_CP091544:207307-207594 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A8S0R9

Antitoxin

Source ID Structure
AlphaFold DB A0A414AJ69

References