Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3192185..3192750 Replicon chromosome
Accession NZ_CP069520
Organism Enterocloster bolteae strain FDAARGOS_1231

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag I6J61_RS14685 Protein ID WP_002596328.1
Coordinates 3192185..3192475 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag I6J61_RS14690 Protein ID WP_005924829.1
Coordinates 3192472..3192750 (-) Length 93 a.a.

Genomic Context

I6J61_RS14655I6J61_RS14660I6J61_RS14665I6J61_RS14670I6J61_RS14675I6J61_RS14680I6J61_RS14695I6J61_RS14700I6J61_RS14705I6J61_RS14710I6J61_RS14715I6J61_RS14720I6J61_RS14725I6J61_RS14730I6J61_RS14685I6J61_RS14690
Location: 3187770..3188231 (462 bp)
Type: Others
Protein ID: WP_038259777.1
Location: 3188685..3189098 (414 bp)
Type: Others
Protein ID: WP_035394329.1
Location: 3189202..3189654 (453 bp)
Type: Others
Protein ID: WP_005933558.1
Location: 3189665..3190126 (462 bp)
Type: Others
Protein ID: WP_035394327.1
Location: 3190155..3190445 (291 bp)
Type: Others
Protein ID: WP_005933556.1
Location: 3190632..3192077 (1446 bp)
Type: Others
Protein ID: WP_007037415.1
Location: 3192877..3193275 (399 bp)
Type: Others
Protein ID: WP_005933550.1
Location: 3193389..3194138 (750 bp)
Type: Others
Protein ID: WP_005933547.1
Location: 3194135..3194998 (864 bp)
Type: Others
Protein ID: WP_005933545.1
Location: 3195042..3195236 (195 bp)
Type: Others
Protein ID: WP_005933543.1
Location: 3195314..3195679 (366 bp)
Type: Others
Protein ID: WP_014080225.1
Location: 3195773..3196588 (816 bp)
Type: Others
Protein ID: Protein_2895
Location: 3196807..3196947 (141 bp)
Type: Others
Protein ID: WP_007037419.1
Location: 3197111..3197416 (306 bp)
Type: Others
Protein ID: WP_002569240.1
Location: 3192185..3192475 (291 bp)
Type: Toxin
Protein ID: WP_002596328.1
Location: 3192472..3192750 (279 bp)
Type: Antitoxin
Protein ID: WP_005924829.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6J61_RS146553187770..3188231+462WP_038259777.1hypothetical protein-
I6J61_RS146603188685..3189098+414WP_035394329.1hypothetical protein-
I6J61_RS146653189202..3189654+453WP_005933558.1hypothetical protein-
I6J61_RS146703189665..3190126+462WP_035394327.1sigma-70 family RNA polymerase sigma factor-
I6J61_RS146753190155..3190445+291WP_005933556.1DUF3847 domain-containing protein-
I6J61_RS146803190632..3192077+1446WP_007037415.1MobA/MobL family protein-
I6J61_RS146853192185..3192475-291WP_002596328.1type II toxin-antitoxin system YafQ family toxinToxin
I6J61_RS146903192472..3192750-279WP_005924829.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
I6J61_RS146953192877..3193275+399WP_005933550.1cysteine-rich VLP domain-containing protein-
I6J61_RS147003193389..3194138+750WP_005933547.1phage replisome organizer N-terminal domain-containing protein-
I6J61_RS147053194135..3194998+864WP_005933545.1ATP-binding protein-
I6J61_RS147103195042..3195236+195WP_005933543.1transposon-encoded TnpW family protein-
I6J61_RS147153195314..3195679+366WP_014080225.1hypothetical protein-
I6J61_RS147203195773..3196588+816Protein_2895type IV secretory system conjugative DNA transfer family protein-
I6J61_RS147253196807..3196947+141WP_007037419.1membrane protein-
I6J61_RS147303197111..3197416+306WP_002569240.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Elementtet(O)-3180174..326436984195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T190759 WP_002596328.1 NZ_CP069520:c3192475-3192185 [Enterocloster bolteae]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T190759 NZ_CP091543:88452-89777 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT190759 WP_005924829.1 NZ_CP069520:c3192750-3192472 [Enterocloster bolteae]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT190759 NZ_CP091543:88154-88447 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1M4XBM1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M4XB19

References