Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 14611..16179 Replicon plasmid unnamed
Accession NZ_CP069519
Organism Salmonella enterica strain FDAARGOS_1271

Toxin (Protein)


Gene name hipA Uniprot ID A0A859R327
Locus tag I6K01_RS22715 Protein ID WP_024134513.1
Coordinates 14872..16179 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A859R2S1
Locus tag I6K01_RS22710 Protein ID WP_039272366.1
Coordinates 14611..14862 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K01_RS22680 10266..10991 + 726 WP_001553093.1 hypothetical protein -
I6K01_RS22685 11047..11499 + 453 WP_001553092.1 hypothetical protein -
I6K01_RS22690 11515..12117 - 603 WP_000278324.1 hypothetical protein -
I6K01_RS22695 12378..12659 + 282 WP_000575656.1 hypothetical protein -
I6K01_RS22700 12678..13241 + 564 WP_001132404.1 hypothetical protein -
I6K01_RS22705 13244..14248 + 1005 WP_001553091.1 tyrosine-type recombinase/integrase -
I6K01_RS22710 14611..14862 + 252 WP_039272366.1 helix-turn-helix domain-containing protein Antitoxin
I6K01_RS22715 14872..16179 + 1308 WP_024134513.1 type II toxin-antitoxin system HipA family toxin Toxin
I6K01_RS22720 16176..16670 + 495 WP_039272364.1 hypothetical protein -
I6K01_RS22725 16846..17784 - 939 WP_000395773.1 hypothetical protein -
I6K01_RS22730 17983..19608 + 1626 WP_001246631.1 PAAR domain-containing protein -
I6K01_RS22735 19980..20282 - 303 WP_001161555.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..128163 128163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-144)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 55901.92 Da        Isoelectric Point: 13.4384

>T190758 WP_024134513.1 NZ_CP069519:14872-16179 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1308 bp

>T190758 NZ_CP091542:4817460-4817771 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT190758 WP_039272366.1 NZ_CP069519:14611-14862 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT190758 NZ_CP091542:4817768-4818214 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A859R327

Antitoxin

Source ID Structure
AlphaFold DB A0A859R2S1

References