Detailed information of TA system TA190753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4627237..4628057
• Replicon: chromosome
• Accession: NZ_CP069517
• Organism: Escherichia coli strain FDAARGOS_1262

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6J92_RS22115
• Protein ID: WP_001054376.1
• Coordinates: 4627800..4628057 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J92_RS22110
• Protein ID: WP_001519303.1
• Coordinates: 4627237..4627788 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J92_RS22075	4622932..4624245	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
I6J92_RS22080	4624257..4624535	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J92_RS22085	4624532..4625653	-	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J92_RS22090	4625898..4626014	-	117	Protein_4313	VOC family protein	-
I6J92_RS22095	4626052..4626312	-	261	WP_000084876.1	hypothetical protein	-
I6J92_RS22100	4626439..4626987	-	549	WP_001519301.1	hypothetical protein	-
I6J92_RS22105	4627024..4627185	-	162	WP_001519302.1	hypothetical protein	-
I6J92_RS22110	4627237..4627788	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
I6J92_RS22115	4627800..4628057	-	258	WP_001054376.1	hypothetical protein	Toxin
I6J92_RS22120	4628434..4628733	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
I6J92_RS22125	4628796..4630037	+	1242	Protein_4320	DNA helicase	-
I6J92_RS22130	4630620..4631600	-	981	WP_001519307.1	transposase	-
I6J92_RS22135	4631665..4632771	-	1107	WP_001519308.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T190753 WP_001054376.1 NZ_CP069517:c4628057-4627800 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190753 NZ_CP091542:3744400-3744675 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT190753 WP_001519303.1 NZ_CP069517:c4627788-4627237 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190753 NZ_CP091542:c3744665-3744243 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: S1PA82