Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4184122..4185110 | Replicon | chromosome |
| Accession | NZ_CP069517 | ||
| Organism | Escherichia coli strain FDAARGOS_1262 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | I6J92_RS19940 | Protein ID | WP_014640052.1 |
| Coordinates | 4184724..4185110 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A0J5Z6D5 |
| Locus tag | I6J92_RS19935 | Protein ID | WP_000458584.1 |
| Coordinates | 4184122..4184694 (+) | Length | 191 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J92_RS19910 | 4180284..4180652 | + | 369 | WP_000002899.1 | diacylglycerol kinase | - |
| I6J92_RS19915 | 4180762..4181370 | + | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| I6J92_RS19920 | 4181443..4182768 | + | 1326 | WP_001296637.1 | MATE family efflux transporter DinF | - |
| I6J92_RS19925 | 4182884..4183093 | + | 210 | WP_001296638.1 | CsbD family protein | - |
| I6J92_RS19930 | 4183135..4183650 | - | 516 | WP_000416264.1 | zinc uptake transcriptional repressor Zur | - |
| I6J92_RS19935 | 4184122..4184694 | + | 573 | WP_000458584.1 | SocA family protein | Antitoxin |
| I6J92_RS19940 | 4184724..4185110 | + | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| I6J92_RS19945 | 4185150..4185323 | + | 174 | WP_021549909.1 | hypothetical protein | - |
| I6J92_RS19950 | 4185371..4185652 | - | 282 | WP_001093919.1 | pyocin activator PrtN family protein | - |
| I6J92_RS19955 | 4185689..4186261 | - | 573 | WP_021549910.1 | 3'-5' exoribonuclease | - |
| I6J92_RS19960 | 4186261..4186857 | - | 597 | WP_021549911.1 | DUF551 domain-containing protein | - |
| I6J92_RS19965 | 4186861..4187148 | - | 288 | WP_021549912.1 | hypothetical protein | - |
| I6J92_RS19970 | 4187150..4187830 | - | 681 | WP_021549913.1 | ead/Ea22-like family protein | - |
| I6J92_RS19975 | 4187832..4188131 | - | 300 | WP_021549914.1 | hypothetical protein | - |
| I6J92_RS19980 | 4188128..4188547 | - | 420 | WP_021549915.1 | hypothetical protein | - |
| I6J92_RS19985 | 4188538..4189074 | - | 537 | WP_000008178.1 | 5'-deoxynucleotidase | - |
| I6J92_RS19990 | 4189203..4190027 | - | 825 | WP_000081295.1 | YfdQ family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4180762..4229679 | 48917 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T190751 WP_014640052.1 NZ_CP069517:4184724-4185110 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
>T190751 NZ_CP091542:2488482-2488766 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
Antitoxin
Download Length: 191 a.a. Molecular weight: 21973.21 Da Isoelectric Point: 6.0283
>AT190751 WP_000458584.1 NZ_CP069517:4184122-4184694 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
Download Length: 573 bp
>AT190751 NZ_CP091542:2488244-2488492 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|