Detailed information of TA system TA190750

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3736055..3736890
• Replicon: chromosome
• Accession: NZ_CP069517
• Organism: Escherichia coli strain FDAARGOS_1262

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6J92_RS17845
• Protein ID: WP_151074857.1
• Coordinates: 3736513..3736890 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6J92_RS17840
• Protein ID: WP_151074858.1
• Coordinates: 3736055..3736423 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J92_RS17805	3731811..3732491	+	681	WP_097505405.1	WYL domain-containing protein	-
I6J92_RS17810	3732753..3733031	+	279	WP_001545361.1	hypothetical protein	-
I6J92_RS17815	3733370..3733681	+	312	WP_097476056.1	hypothetical protein	-
I6J92_RS17820	3733780..3734598	+	819	WP_097476057.1	DUF945 domain-containing protein	-
I6J92_RS17825	3734690..3735175	+	486	WP_097476058.1	antirestriction protein	-
I6J92_RS17830	3735191..3735667	+	477	WP_021530763.1	RadC family protein	-
I6J92_RS17835	3735754..3735975	+	222	WP_000692350.1	DUF987 domain-containing protein	-
I6J92_RS17840	3736055..3736423	+	369	WP_151074858.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J92_RS17845	3736513..3736890	+	378	WP_151074857.1	TA system toxin CbtA family protein	Toxin
I6J92_RS17850	3736887..3737375	+	489	WP_204148018.1	hypothetical protein	-
I6J92_RS17855	3737386..3737583	+	198	WP_204148019.1	hypothetical protein	-
I6J92_RS17860	3737668..3738510	+	843	WP_097475970.1	DUF4942 domain-containing protein	-
I6J92_RS17865	3739106..3739603	+	498	WP_000509810.1	hypothetical protein	-
I6J92_RS17870	3739770..3740693	+	924	WP_001445306.1	carboxylate/amino acid/amine transporter	-
I6J92_RS17875	3740697..3741515	-	819	WP_000779409.1	lipoprotein NlpA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3729661..3739603	9942

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14119.11 Da
• Isoelectric Point: 7.2919

>T190750 WP_151074857.1 NZ_CP069517:3736513-3736890 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILWARRATGLMTRDNYRTVNGITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T190750 NZ_CP091542:2119159-2119314 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13540.24 Da
• Isoelectric Point: 6.4753

>AT190750 WP_151074858.1 NZ_CP069517:3736055-3736423 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYIAIYPTPGTKT

Nucleotide

• Length: 369 bp

>AT190750 NZ_CP091542:c2119147-2119089 [Salmonella enterica subsp. enterica serovar Typhimurium]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA