Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 28489..29107 | Replicon | chromosome |
Accession | NZ_CP069517 | ||
Organism | Escherichia coli strain FDAARGOS_1262 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | I6J92_RS00140 | Protein ID | WP_001291435.1 |
Coordinates | 28489..28707 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | I6J92_RS00145 | Protein ID | WP_000344800.1 |
Coordinates | 28733..29107 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J92_RS00105 | 23777..24349 | + | 573 | WP_000779844.1 | YbaY family lipoprotein | - |
I6J92_RS00110 | 24380..24691 | - | 312 | WP_000409908.1 | MGMT family protein | - |
I6J92_RS00120 | 25070..25423 | + | 354 | WP_000878142.1 | DUF1428 family protein | - |
I6J92_RS00125 | 25465..27015 | - | 1551 | WP_001468081.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
I6J92_RS00130 | 27179..27649 | - | 471 | WP_000136192.1 | YlaC family protein | - |
I6J92_RS00135 | 27765..28316 | - | 552 | WP_000102539.1 | maltose O-acetyltransferase | - |
I6J92_RS00140 | 28489..28707 | - | 219 | WP_001291435.1 | hemolysin expression modulator Hha | Toxin |
I6J92_RS00145 | 28733..29107 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
I6J92_RS00150 | 29652..32801 | - | 3150 | WP_001132469.1 | multidrug efflux RND transporter permease subunit | - |
I6J92_RS00155 | 32824..34017 | - | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T190732 WP_001291435.1 NZ_CP069517:c28707-28489 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T190732 NZ_CP091540:2119103-2119258 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT190732 WP_000344800.1 NZ_CP069517:c29107-28733 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT190732 NZ_CP091540:c2119091-2119033 [Salmonella enterica subsp. enterica serovar Typhimurium]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |