Detailed information of TA system TA190731

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1836597..1837228
• Replicon: chromosome
• Accession: NZ_CP069510
• Organism: Haemophilus parahaemolyticus strain FDAARGOS_1199

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6J29_RS08920
• Protein ID: WP_005706920.1
• Coordinates: 1836597..1836995 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I2NCV5
• Locus tag: I6J29_RS08925
• Protein ID: WP_005706948.1
• Coordinates: 1836995..1837228 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J29_RS08905	1832968..1833681	-	714	WP_143413720.1	hypothetical protein	-
I6J29_RS08910	1833918..1834844	+	927	WP_005706977.1	zinc ABC transporter substrate-binding protein ZnuA	-
I6J29_RS08915	1835042..1836577	-	1536	WP_005706963.1	L-2,4-diaminobutyrate decarboxylase	-
I6J29_RS08920	1836597..1836995	-	399	WP_005706920.1	tRNA(fMet)-specific endonuclease VapC	Toxin
I6J29_RS08925	1836995..1837228	-	234	WP_005706948.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I6J29_RS08930	1837375..1838739	-	1365	WP_005706918.1	diaminobutyrate--2-oxoglutarate transaminase	-
I6J29_RS08935	1839091..1839261	-	171	WP_005706939.1	50S ribosomal protein L33	-
I6J29_RS08940	1839273..1839509	-	237	WP_005599762.1	50S ribosomal protein L28	-
I6J29_RS08945	1839757..1840335	-	579	Protein_1716	molecular chaperone TorD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15057.37 Da
• Isoelectric Point: 8.0500

>T190731 WP_005706920.1 NZ_CP069510:c1836995-1836597 [Haemophilus parahaemolyticus]
VLKYMLDTNIVIYVIKRRPLEVLSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNLAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLKEFERVPALRTENWV

Nucleotide

• Length: 399 bp

>T190731 NZ_CP091540:c2106711-2106517 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACAG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8907.06 Da
• Isoelectric Point: 4.4013

>AT190731 WP_005706948.1 NZ_CP069510:c1837228-1836995 [Haemophilus parahaemolyticus]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVLGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT190731 NZ_CP091540:2106342-2106518 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGAGA
GCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTTCA
ATAGTGGCAGTTATTTT

Structures

Antitoxin

• AlphaFold DB: I2NCV5