Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1528871..1529442 Replicon chromosome
Accession NZ_CP069510
Organism Haemophilus parahaemolyticus strain FDAARGOS_1199

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6J29_RS07335 Protein ID WP_039863090.1
Coordinates 1529158..1529442 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3DL00
Locus tag I6J29_RS07330 Protein ID WP_005706005.1
Coordinates 1528871..1529152 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J29_RS07305 1523930..1524295 + 366 WP_005705952.1 CrcB family protein -
I6J29_RS07310 1524397..1525719 - 1323 WP_005705951.1 anaerobic C4-dicarboxylate transporter -
I6J29_RS07315 1525860..1526684 + 825 WP_005705939.1 diaminopimelate epimerase -
I6J29_RS07320 1526698..1527267 + 570 WP_005705985.1 DUF5358 domain-containing protein -
I6J29_RS07325 1527348..1528772 - 1425 WP_005705988.1 DUF560 domain-containing protein -
I6J29_RS07330 1528871..1529152 + 282 WP_005706005.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J29_RS07335 1529158..1529442 + 285 WP_039863090.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
I6J29_RS07340 1529528..1530520 - 993 WP_005706914.1 IS110 family transposase -
I6J29_RS07345 1530769..1532310 - 1542 WP_177875765.1 hypothetical protein -
I6J29_RS07350 1532443..1532847 + 405 WP_005706498.1 helix-turn-helix domain-containing protein -
I6J29_RS07355 1532903..1533697 - 795 WP_005706495.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-72)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11113.01 Da        Isoelectric Point: 9.7710

>T190730 WP_039863090.1 NZ_CP069510:1529158-1529442 [Haemophilus parahaemolyticus]
MESVKTLKVTATKTFQRDIKKLTAKQQFSVEMTEVLYLLQRNRPLPRKYLDHALQGEMQGYRNCHIFSDLVLIYQIIDDK
ELKLIRIGSHSEIF

Download         Length: 285 bp

>T190730 NZ_CP091540:2104672-2104775 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10507.84 Da        Isoelectric Point: 4.2420

>AT190730 WP_005706005.1 NZ_CP069510:1528871-1529152 [Haemophilus parahaemolyticus]
MTQNASFSFRLSENLKQEAFNVIENYGFTPSQVFNLFLTEIANTKTIPVNLSYLKPNAETLRAMQEAENGDVDIISEANF
EANIMENLLKSVK

Download         Length: 282 bp

>AT190730 NZ_CP091540:c2104776-2104632 [Salmonella enterica subsp. enterica serovar Typhimurium]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3DL00

References