Detailed information of TA system TA190728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1411912..1412314
• Replicon: chromosome
• Accession: NZ_CP069510
• Organism: Haemophilus parahaemolyticus strain FDAARGOS_1199

Toxin (Protein)

• Gene name: -
• Uniprot ID: I3DIU0
• Locus tag: I6J29_RS06640
• Protein ID: WP_005706090.1
• Coordinates: 1411912..1412076 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I3DIU1
• Locus tag: I6J29_RS06645
• Protein ID: WP_005706091.1
• Coordinates: 1412060..1412314 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J29_RS06635	1407212..1411600	-	4389	WP_115364329.1	hypothetical protein	-
I6J29_RS06640	1411912..1412076	+	165	WP_005706090.1	BrnT family toxin	Toxin
I6J29_RS06645	1412060..1412314	+	255	WP_005706091.1	hypothetical protein	Antitoxin
I6J29_RS06650	1412460..1412792	+	333	WP_005706088.1	multidrug transporter	-
I6J29_RS06655	1412877..1413416	+	540	WP_005706089.1	alpha/beta hydrolase	-
I6J29_RS06665	1413822..1415210	+	1389	WP_005705932.1	DASS family sodium-coupled anion symporter	-
I6J29_RS06670	1415340..1416059	+	720	WP_005705933.1	1-acylglycerol-3-phosphate O-acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6479.51 Da
• Isoelectric Point: 10.5393

>T190728 WP_005706090.1 NZ_CP069510:1411912-1412076 [Haemophilus parahaemolyticus]
MFEYDPNKSEIKLGIAKLNDKHWSAIFTLRGKNIRLISVRRSRKKEIELYETNQ

Nucleotide

• Length: 165 bp

>T190728 NZ_CP091540:849190-849588 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9887.35 Da
• Isoelectric Point: 5.6227

>AT190728 WP_005706091.1 NZ_CP069510:1412060-1412314 [Haemophilus parahaemolyticus]
MKPINNIEFDHIFDENEEDIVEYLELTSAKRPNQKTKRVNVDFPLWMVESLDKEAAHLGVPRQALIKLWISEKLPVYKNH
LQTA

Nucleotide

• Length: 255 bp

>AT190728 NZ_CP091540:848963-849190 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: I3DIU0

Antitoxin

• AlphaFold DB: I3DIU1