Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 550123..550767 | Replicon | chromosome |
| Accession | NZ_CP069510 | ||
| Organism | Haemophilus parahaemolyticus strain FDAARGOS_1199 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A369YIM4 |
| Locus tag | I6J29_RS02710 | Protein ID | WP_039863182.1 |
| Coordinates | 550123..550308 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | I3DGZ2 |
| Locus tag | I6J29_RS02715 | Protein ID | WP_005706311.1 |
| Coordinates | 550339..550767 (+) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J29_RS02690 | 546201..548009 | + | 1809 | WP_005706296.1 | terminase family protein | - |
| I6J29_RS02695 | 548090..549061 | + | 972 | WP_100208021.1 | phage portal protein | - |
| I6J29_RS02700 | 549131..549418 | + | 288 | WP_005706325.1 | ogr/Delta-like zinc finger family protein | - |
| I6J29_RS02705 | 549708..549890 | + | 183 | WP_005706302.1 | hypothetical protein | - |
| I6J29_RS02710 | 550123..550308 | + | 186 | WP_039863182.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| I6J29_RS02715 | 550339..550767 | + | 429 | WP_005706311.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| I6J29_RS02720 | 550793..550864 | + | 72 | WP_115364335.1 | type II toxin-antitoxin system HicA family toxin | - |
| I6J29_RS02725 | 550891..551301 | + | 411 | WP_005706322.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| I6J29_RS02730 | 551359..551580 | - | 222 | WP_005706351.1 | hypothetical protein | - |
| I6J29_RS02735 | 551591..552115 | - | 525 | WP_039863201.1 | phage N-6-adenine-methyltransferase | - |
| I6J29_RS02740 | 552132..554675 | - | 2544 | WP_005706317.1 | replication endonuclease | - |
| I6J29_RS02745 | 554708..554941 | - | 234 | WP_005706295.1 | hypothetical protein | - |
| I6J29_RS02750 | 554951..555202 | - | 252 | WP_005706342.1 | hypothetical protein | - |
| I6J29_RS02755 | 555205..555369 | - | 165 | WP_005706341.1 | hypothetical protein | - |
| I6J29_RS02760 | 555347..555655 | - | 309 | WP_005706334.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 527591..568087 | 40496 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6788.00 Da Isoelectric Point: 11.0781
>T190727 WP_039863182.1 NZ_CP069510:550123-550308 [Haemophilus parahaemolyticus]
MRSSDLIKELKKAGCTFERHGKGDHQIWKSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKKAGCTFERHGKGDHQIWKSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T190727 NZ_CP091540:838323-838736 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
Antitoxin
Download Length: 143 a.a. Molecular weight: 16308.32 Da Isoelectric Point: 4.3994
>AT190727 WP_005706311.1 NZ_CP069510:550339-550767 [Haemophilus parahaemolyticus]
MLFTIGIETPANENEAYGIAVPALSTEKYDCFSAADTLEEIPTQATDAIHSILEMMFEDGLDINELQDKGYRHYQTLEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAVASQKELRQ
MLFTIGIETPANENEAYGIAVPALSTEKYDCFSAADTLEEIPTQATDAIHSILEMMFEDGLDINELQDKGYRHYQTLEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAVASQKELRQ
Download Length: 429 bp
>AT190727 NZ_CP091540:838076-838342 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A369YIM4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3DGZ2 |