190722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 3717..4266 Replicon plasmid unnamed3
Accession NZ_CP069507
Organism Acinetobacter pittii strain FDAARGOS_1215

Toxin (Protein)


Gene name relE Uniprot ID N9KJ78
Locus tag I6J45_RS18165 Protein ID WP_000176412.1
Coordinates 3976..4266 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9KCM7
Locus tag I6J45_RS18160 Protein ID WP_005140357.1
Coordinates 3717..3992 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J45_RS18135 1..9084 - 9084 WP_000179382.1 MobA/MobL family protein -
I6J45_RS18140 613..1389 + 777 WP_000191151.1 hypothetical protein -
I6J45_RS18145 1614..2813 + 1200 WP_005804948.1 hypothetical protein -
I6J45_RS18150 2886..3128 - 243 WP_001015364.1 hypothetical protein -
I6J45_RS18155 3277..3501 + 225 WP_002072934.1 hypothetical protein -
I6J45_RS18160 3717..3992 + 276 WP_005140357.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J45_RS18165 3976..4266 + 291 WP_000176412.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6J45_RS18170 4314..4460 - 147 WP_000192351.1 hypothetical protein -
I6J45_RS18175 4457..4978 - 522 WP_000999915.1 hypothetical protein -
I6J45_RS18180 5503..5820 - 318 WP_005065053.1 hypothetical protein -
I6J45_RS18185 6171..6737 - 567 WP_000858429.1 plasmid replication DNA-binding protein -
I6J45_RS18190 6801..7682 - 882 WP_005804946.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9084 9084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-96)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(9-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11187.12 Da        Isoelectric Point: 6.9783

>T190722 WP_000176412.1 NZ_CP069507:3976-4266 [Acinetobacter pittii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Download         Length: 291 bp

>T190722 NZ_CP091535:c62454-62305 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10290.65 Da        Isoelectric Point: 4.6702

>AT190722 WP_005140357.1 NZ_CP069507:3717-3992 [Acinetobacter pittii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Download         Length: 276 bp

>AT190722 NZ_CP091535:62498-62559 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9KJ78

Antitoxin

Source ID Structure
AlphaFold DB N9KCM7

References