190718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1757..2342 Replicon plasmid unnamed1
Accession NZ_CP069505
Organism Acinetobacter pittii strain FDAARGOS_1215

Toxin (Protein)


Gene name brnT Uniprot ID A0A158LPL9
Locus tag I6J45_RS17605 Protein ID WP_002124950.1
Coordinates 1757..2044 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A062GCE4
Locus tag I6J45_RS17610 Protein ID WP_005065064.1
Coordinates 2031..2342 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J45_RS17605 1757..2044 + 288 WP_002124950.1 BrnT family toxin Toxin
I6J45_RS17610 2031..2342 + 312 WP_005065064.1 BrnA antitoxin family protein Antitoxin
I6J45_RS17615 2433..3107 - 675 WP_005065062.1 HEPN domain-containing protein -
I6J45_RS17620 3159..3560 - 402 WP_005065059.1 hypothetical protein -
I6J45_RS17625 3652..3954 - 303 WP_005065057.1 XRE family transcriptional regulator -
I6J45_RS17630 3959..4303 - 345 WP_005065055.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6J45_RS17635 4824..5141 - 318 WP_000900860.1 hypothetical protein -
I6J45_RS17640 5491..6021 - 531 WP_005065050.1 plasmid replication DNA-binding protein -
I6J45_RS17645 6100..7029 - 930 WP_005065049.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11158 11158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.58 Da        Isoelectric Point: 4.9093

>T190718 WP_002124950.1 NZ_CP069505:1757-2044 [Acinetobacter pittii]
MELYFEWDEAKNQKNQKKHDVSFETASLVFEDPLRISIQDRHTNGEERWQTIGMVKGVLMLLVAHTIIDDDDCEIIRIIS
ARQVTKAERNQYEHG

Download         Length: 288 bp

>T190718 NZ_CP091534:2852518-2852625 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12070.80 Da        Isoelectric Point: 9.4651

>AT190718 WP_005065064.1 NZ_CP069505:2031-2342 [Acinetobacter pittii]
MSMVRYTRKELNEKFSDKQDAEIKRLLAKGTVPDEQLDLSDIPEITDWSHAVRHGQFYRPVKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLEDLKNH

Download         Length: 312 bp

>AT190718 NZ_CP091534:c2852465-2852404 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A158LPL9

Antitoxin

Source ID Structure
AlphaFold DB A0A062GCE4

References