Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 361513..362166 Replicon chromosome
Accession NZ_CP069504
Organism Acinetobacter pittii strain FDAARGOS_1215

Toxin (Protein)


Gene name cptA Uniprot ID A0A009NMD1
Locus tag I6J45_RS01805 Protein ID WP_005804615.1
Coordinates 361777..362166 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag I6J45_RS01800 Protein ID WP_002117064.1
Coordinates 361513..361770 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J45_RS01780 357026..358033 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
I6J45_RS01785 358052..358429 + 378 WP_002049717.1 50S ribosomal protein L17 -
I6J45_RS01790 358611..360101 + 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
I6J45_RS01795 360152..361324 - 1173 WP_025464188.1 acyl-CoA dehydrogenase family protein -
I6J45_RS01800 361513..361770 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
I6J45_RS01805 361777..362166 + 390 WP_005804615.1 hypothetical protein Toxin
I6J45_RS01810 362937..364025 + 1089 WP_005804616.1 hypothetical protein -
I6J45_RS01815 364110..364685 + 576 WP_025464189.1 rhombosortase -
I6J45_RS01820 364865..367075 + 2211 WP_005804618.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15553.65 Da        Isoelectric Point: 8.7390

>T190717 WP_005804615.1 NZ_CP069504:361777-362166 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSIAYFSKKEI
YRGEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T190717 NZ_CP091534:2851982-2852089 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT190717 WP_002117064.1 NZ_CP069504:361513-361770 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT190717 NZ_CP091534:c2851935-2851869 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009NMD1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References