Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1564180..1564885 Replicon chromosome
Accession NZ_CP069501
Organism Escherichia coli strain FDAARGOS_1268

Toxin (Protein)


Gene name relE Uniprot ID A0A1M2J6W7
Locus tag I6J98_RS07510 Protein ID WP_000539524.1
Coordinates 1564499..1564885 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6J98_RS07505 Protein ID WP_001280945.1
Coordinates 1564180..1564509 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J98_RS07490 1559338..1560249 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
I6J98_RS07495 1560426..1562774 + 2349 WP_000950331.1 EAL domain-containing protein -
I6J98_RS07500 1562782..1564110 + 1329 WP_000086870.1 GGDEF domain-containing protein -
I6J98_RS07505 1564180..1564509 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
I6J98_RS07510 1564499..1564885 - 387 WP_000539524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J98_RS07515 1565111..1566436 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
I6J98_RS07520 1566649..1567032 + 384 WP_000497137.1 biofilm formation regulator BssR -
I6J98_RS07525 1567143..1568258 + 1116 WP_000555056.1 aldose sugar dehydrogenase YliI -
I6J98_RS07530 1568255..1568881 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14321.46 Da        Isoelectric Point: 9.9521

>T190697 WP_000539524.1 NZ_CP069501:c1564885-1564499 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T190697 NZ_CP091527:c3216894-3216792 [Klebsiella sp. PCX]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT190697 WP_001280945.1 NZ_CP069501:c1564509-1564180 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT190697 NZ_CP091527:3216788-3216935 [Klebsiella sp. PCX]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2J6W7

Antitoxin

Source ID Structure

References