Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4977144..4977945 Replicon chromosome
Accession NZ_CP069500
Organism Escherichia coli strain FDAARGOS_1258

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag I6J88_RS24220 Protein ID WP_000854739.1
Coordinates 4977565..4977945 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I6J88_RS24215 Protein ID WP_001285482.1
Coordinates 4977144..4977518 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J88_RS24175 4973156..4973611 + 456 WP_000581502.1 hypothetical protein -
I6J88_RS24180 4973730..4973941 - 212 Protein_4589 hypothetical protein -
I6J88_RS24185 4974022..4974843 + 822 WP_001535267.1 DUF945 domain-containing protein -
I6J88_RS24190 4974843..4975088 + 246 WP_001164966.1 hypothetical protein -
I6J88_RS24195 4975182..4975655 + 474 WP_001313575.1 antirestriction protein -
I6J88_RS24200 4975671..4976147 + 477 WP_001313574.1 RadC family protein -
I6J88_RS24205 4976210..4976431 + 222 WP_000692315.1 DUF987 domain-containing protein -
I6J88_RS24210 4976450..4977094 + 645 WP_000086759.1 hypothetical protein -
I6J88_RS24215 4977144..4977518 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J88_RS24220 4977565..4977945 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
I6J88_RS24225 4977942..4978430 + 489 WP_001518535.1 hypothetical protein -
I6J88_RS24230 4978450..4978647 + 198 WP_000772027.1 DUF957 domain-containing protein -
I6J88_RS24235 4978732..4979559 + 828 WP_001518536.1 DUF4942 domain-containing protein -
I6J88_RS24245 4980045..4980983 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
I6J88_RS24250 4981038..4981775 + 738 WP_000283664.1 zinc-binding phosphatase -
I6J88_RS24255 4981799..4982353 + 555 WP_001001921.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T190688 WP_000854739.1 NZ_CP069500:4977565-4977945 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T190688 NZ_CP091525:2417375-2417482 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT190688 WP_001285482.1 NZ_CP069500:4977144-4977518 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT190688 NZ_CP091525:c2417559-2417499 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References