190687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4273834..4274452 Replicon chromosome
Accession NZ_CP069500
Organism Escherichia coli strain FDAARGOS_1258

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6J88_RS20825 Protein ID WP_001291435.1
Coordinates 4273834..4274052 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6J88_RS20830 Protein ID WP_000344800.1
Coordinates 4274078..4274452 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J88_RS20790 4269122..4269694 + 573 WP_000779844.1 YbaY family lipoprotein -
I6J88_RS20795 4269725..4270036 - 312 WP_000409908.1 MGMT family protein -
I6J88_RS20805 4270415..4270768 + 354 WP_000878142.1 DUF1428 family protein -
I6J88_RS20810 4270810..4272360 - 1551 WP_001468081.1 cyclic-guanylate-specific phosphodiesterase PdeB -
I6J88_RS20815 4272524..4272994 - 471 WP_000136192.1 YlaC family protein -
I6J88_RS20820 4273110..4273661 - 552 WP_000102539.1 maltose O-acetyltransferase -
I6J88_RS20825 4273834..4274052 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
I6J88_RS20830 4274078..4274452 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
I6J88_RS20835 4274997..4278146 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
I6J88_RS20840 4278169..4279362 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T190687 WP_001291435.1 NZ_CP069500:c4274052-4273834 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T190687 NZ_CP091525:2386090-2386356 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT190687 WP_000344800.1 NZ_CP069500:c4274452-4274078 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT190687 NZ_CP091525:2385833-2386090 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References