Detailed information of TA system TA190682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3653660..3654480
• Replicon: chromosome
• Accession: NZ_CP069500
• Organism: Escherichia coli strain FDAARGOS_1258

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6J88_RS17830
• Protein ID: WP_001054376.1
• Coordinates: 3654223..3654480 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J88_RS17825
• Protein ID: WP_001519303.1
• Coordinates: 3653660..3654211 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J88_RS17790	3649355..3650668	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
I6J88_RS17795	3650680..3650958	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J88_RS17800	3650955..3652076	-	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J88_RS17805	3652321..3652437	-	117	Protein_3344	VOC family protein	-
I6J88_RS17810	3652475..3652735	-	261	WP_000084876.1	hypothetical protein	-
I6J88_RS17815	3652862..3653410	-	549	WP_001519301.1	hypothetical protein	-
I6J88_RS17820	3653447..3653608	-	162	WP_001519302.1	hypothetical protein	-
I6J88_RS17825	3653660..3654211	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
I6J88_RS17830	3654223..3654480	-	258	WP_001054376.1	hypothetical protein	Toxin
I6J88_RS17835	3654857..3655156	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
I6J88_RS17840	3655219..3656460	+	1242	Protein_3351	DNA helicase	-
I6J88_RS17845	3657043..3658023	-	981	WP_001519307.1	transposase	-
I6J88_RS17850	3658088..3659194	-	1107	WP_001519308.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimI / fimC	3627076..3665464	38388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T190682 WP_001054376.1 NZ_CP069500:c3654480-3654223 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190682 NZ_CP091525:18786-18962 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT190682 WP_001519303.1 NZ_CP069500:c3654211-3653660 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190682 NZ_CP091525:c19124-18950 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: S1PA82