Detailed information of TA system TA190679

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1952470..1953305
• Replicon: chromosome
• Accession: NZ_CP069500
• Organism: Escherichia coli strain FDAARGOS_1258

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A836N5X5
• Locus tag: I6J88_RS09780
• Protein ID: WP_016238532.1
• Coordinates: 1952928..1953305 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6J88_RS09775
• Protein ID: WP_016238531.1
• Coordinates: 1952470..1952838 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J88_RS09740	1948755..1949210	+	456	WP_016238357.1	hypothetical protein	-
I6J88_RS09745	1949289..1949522	+	234	WP_001119727.1	DUF905 family protein	-
I6J88_RS09750	1949623..1950441	+	819	WP_021533742.1	DUF945 domain-containing protein	-
I6J88_RS09755	1950496..1950981	+	486	WP_000849565.1	antirestriction protein	-
I6J88_RS09760	1950997..1951473	+	477	WP_001186727.1	RadC family protein	-
I6J88_RS09765	1951536..1951757	+	222	WP_000692329.1	DUF987 domain-containing protein	-
I6J88_RS09770	1951776..1952420	+	645	WP_000094917.1	hypothetical protein	-
I6J88_RS09775	1952470..1952838	+	369	WP_016238531.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J88_RS09780	1952928..1953305	+	378	WP_016238532.1	TA system toxin CbtA family protein	Toxin
I6J88_RS09785	1953302..1953790	+	489	WP_016238533.1	hypothetical protein	-
I6J88_RS09790	1953807..1954004	+	198	WP_000839260.1	DUF957 domain-containing protein	-
I6J88_RS09795	1954089..1954934	+	846	WP_001280441.1	DUF4942 domain-containing protein	-
I6J88_RS09800	1955003..1955398	+	396	WP_000208383.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
I6J88_RS09805	1955391..1955933	+	543	Protein_1789	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6J88_RS09810	1956028..1957527	+	1500	WP_016238535.1	IS21-like element ISEc10 family transposase	-
I6J88_RS09815	1957524..1958279	+	756	WP_000065240.1	IS21-like element ISEc10 family helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14116.04 Da
• Isoelectric Point: 7.3842

>T190679 WP_016238532.1 NZ_CP069500:1952928-1953305 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDMLRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T190679 NZ_CP091523:2678999-2679103 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13694.46 Da
• Isoelectric Point: 6.4768

>AT190679 WP_016238531.1 NZ_CP069500:1952470-1952838 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT190679 NZ_CP091523:c2679261-2679098 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A836N5X5