Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 3746..4295 Replicon plasmid unnamed1
Accession NZ_CP069497
Organism Acinetobacter pittii strain FDAARGOS_1217

Toxin (Protein)


Gene name relE Uniprot ID N9KJ78
Locus tag I6J47_RS18350 Protein ID WP_000176412.1
Coordinates 4005..4295 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9KCM7
Locus tag I6J47_RS18345 Protein ID WP_005140357.1
Coordinates 3746..4021 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J47_RS18320 1..9060 - 9060 WP_000179382.1 MobA/MobL family protein -
I6J47_RS18325 666..1442 + 777 WP_000191151.1 hypothetical protein -
I6J47_RS18330 1667..2866 + 1200 WP_002072939.1 hypothetical protein -
I6J47_RS18335 2939..3181 - 243 WP_001015364.1 hypothetical protein -
I6J47_RS18340 3330..3554 + 225 WP_002072934.1 hypothetical protein -
I6J47_RS18345 3746..4021 + 276 WP_005140357.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J47_RS18350 4005..4295 + 291 WP_000176412.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6J47_RS18355 4343..4489 - 147 WP_000192351.1 hypothetical protein -
I6J47_RS18360 4486..5007 - 522 WP_000999915.1 hypothetical protein -
I6J47_RS18365 5532..5849 - 318 WP_005065053.1 hypothetical protein -
I6J47_RS18370 6200..6766 - 567 WP_000858429.1 plasmid replication DNA-binding protein -
I6J47_RS18375 6830..7711 - 882 WP_005804946.1 replication initiation protein RepM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9060 9060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-96)

Antitoxin

(9-75)


Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11187.12 Da        Isoelectric Point: 6.9783

>T190657 WP_000176412.1 NZ_CP069497:4005-4295 [Acinetobacter pittii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Download         Length: 291 bp

>T190657 NZ_CP091518:647429-647698 [Kingella kingae]
ATGAGCAGAGAAATTATTTTTCAAGGGCAGTTTAAGCGAGATGTGAAAAAGCAGTTTTTAGAGCTTGCGACAGTGGAATG
GGCAGAAGTTTTAACTTGTTTGGTAAATGATTTGCCGCTTGCTGAAAAATATCGCGACCATGCGCTTGTGAATGACAAAA
ACGGATACAGAGACTGCCATATCAAGCCTGATTTGGTTTTAATTTACGGCAGGAAAGAAAACGCCTTGATACTTGTTCGG
TTAGGTTCTCATTCCGAGATATTTGGCTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10290.65 Da        Isoelectric Point: 4.6702

>AT190657 WP_005140357.1 NZ_CP069497:3746-4021 [Acinetobacter pittii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Download         Length: 276 bp

>AT190657 NZ_CP091518:647148-647432 [Kingella kingae]
ATGAGCGCAATAAATTTTAATATCCGTATGGATAAAAGTTTGAAAGAACGCGCATTTCCAGTCATTGAGAGCTACGGATT
AACGCCAGCACAAGCAGTCAAACTGTTTTTTAATCAGATTGCTACTACCCAAACCATTCCCATTTCATTTGAACACAACG
TAAACCGCATTCCTAATGCAATCACACGTAAAGCGATTGAAGATGCGGAATCCGAATTTGAGACAGCCAAACGCTATAAA
ACCGTTGAAGAAGCTATTGCAGCAATGCAGGAATTGGCGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB N9KJ78


Antitoxin

Source ID Structure
AlphaFold DB N9KCM7

References