Detailed information of TA system TA190655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1555305..1555984
• Replicon: chromosome
• Accession: NZ_CP069496
• Organism: Acinetobacter pittii strain FDAARGOS_1217

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: I6J47_RS07550
• Protein ID: WP_000838146.1
• Coordinates: 1555802..1555984 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A915WMT7
• Locus tag: I6J47_RS07545
• Protein ID: WP_023187967.1
• Coordinates: 1555305..1555709 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J47_RS07535	1554261..1554524	-	264	WP_001275792.1	hypothetical protein	-
I6J47_RS07540	1554526..1555206	-	681	WP_000721572.1	hypothetical protein	-
I6J47_RS07545	1555305..1555709	-	405	WP_023187967.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6J47_RS07550	1555802..1555984	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6J47_RS07555	1556310..1556537	-	228	Protein_1496	hypothetical protein	-
I6J47_RS07560	1556533..1556733	-	201	Protein_1497	hypothetical protein	-
I6J47_RS07565	1556773..1558065	-	1293	WP_005802767.1	terminase family protein	-
I6J47_RS07570	1558025..1558540	-	516	WP_000729387.1	DUF2280 domain-containing protein	-
I6J47_RS07575	1558599..1559240	-	642	WP_002121497.1	hypothetical protein	-
I6J47_RS07580	1559209..1559643	-	435	WP_002121499.1	hypothetical protein	-
I6J47_RS07585	1559703..1560158	-	456	WP_001136775.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T190655 WP_000838146.1 NZ_CP069496:c1555984-1555802 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T190655 NZ_CP091517:c19129-18944 [Kingella potus]
ATGAAAAGCAGGGAGTTAATCGCTATTCTCGAAGCCGGCGGCTGGCAGCTTGTCCGAGTGAAAGGCAGCCACCATCAGTT
TAAGAAAGACGGCGTTCCACACTTGATTACCATCAGCCATCCCGAAAAAGACGTATCTTTGGGGCAACTGAAAGATGCAA
AAAAGAAATCGGGTTTGGATTTTTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14663.74 Da
• Isoelectric Point: 4.4328

>AT190655 WP_023187967.1 NZ_CP069496:c1555709-1555305 [Acinetobacter pittii]
MLYLIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT190655 NZ_CP091517:c18890-18483 [Kingella potus]
ATGATTTACTATCCGGCCGCCCTGTTTCAAGATGCGGGGCAAAGCGGCTACGGCATAGTCATTCCCGACCTGCCCGGCTG
CTATCCTGTGGGCGATACGGTGGAGGAGGCCTTGGCCGACGCGAAAGCCGCCGCCGCGTTCCACATTGAGGGCATGATTG
CCGAGAGCTTGGAATATGTTACCGCGCCGCGCGGCATTGCCGAGCTGCGCAGCCTGCCCGATTATGCCGACGCGCTTATG
TGGGTGTTGGTAGAGGTGGATGAAACCGTGTTTTCCAAACAGACGCGCTTCAATGTGAGCTGGCCGCAGTATTTGCTCGA
CCGCGTGGACGAATACACCGCCATACACCATGAAACACGCAGCGGCTTTCTCGCCCGTGCCGCGCTGGACGCGCTCAACC
GTTCCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7