Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 2061013..2061496 Replicon chromosome
Accession NZ_CP069495
Organism Kytococcus sedentarius strain FDAARGOS_1200

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6J30_RS09685 Protein ID WP_204159641.1
Coordinates 2061013..2061279 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag I6J30_RS09690 Protein ID WP_015780318.1
Coordinates 2061263..2061496 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J30_RS09660 2056768..2057985 - 1218 WP_015780313.1 MFS transporter -
I6J30_RS09665 2057992..2059083 - 1092 WP_015780314.1 SagB/ThcOx family dehydrogenase -
I6J30_RS09670 2059080..2060123 - 1044 WP_204159640.1 hypothetical protein -
I6J30_RS09675 2060723..2060869 + 147 WP_169307799.1 hypothetical protein -
I6J30_RS09680 2060874..2061011 + 138 WP_015780316.1 hypothetical protein -
I6J30_RS09685 2061013..2061279 - 267 WP_204159641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J30_RS09690 2061263..2061496 - 234 WP_015780318.1 ribbon-helix-helix protein, CopG family Antitoxin
I6J30_RS09695 2061588..2062100 - 513 WP_169307800.1 hypothetical protein -
I6J30_RS09700 2062263..2063162 + 900 WP_204159642.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
I6J30_RS09705 2063383..2063973 + 591 WP_204159643.1 hypothetical protein -
I6J30_RS09710 2064158..2065015 + 858 WP_204159644.1 hypothetical protein -
I6J30_RS09715 2065030..2065383 - 354 WP_204159645.1 DUF4229 domain-containing protein -
I6J30_RS09720 2065387..2066280 - 894 WP_204159646.1 c-type cytochrome biogenesis protein CcsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9920.49 Da        Isoelectric Point: 9.0685

>T190653 WP_204159641.1 NZ_CP069495:c2061279-2061013 [Kytococcus sedentarius]
MAWTVEVSATARKALKKLGPPVARRIVRFLRELEALDDPRARGKALTGVLSGLWRYRVGDHRVICDLDDEVLVVHVIEVG
HRSSVYDD

Download         Length: 267 bp

>T190653 NZ_CP091516:1212116-1212415 [Kingella potus]
ATGACAAAAACCATCCCATTCGATCCTGCCCGCTACCTGAAAAACGAAGAGGAAATAGCCGTTTATTTGGAAGTGGCCGC
CGAAGAGGCGGCAGAGGCCGGAGACAACAGCATTTTGCTGCGAGCCATCAATACCGCCGCCAAAGCGCGGGGCATGATGG
AAATAGCCAAACAGGCGGGCGTTTCCCGCGAAAGCCTGTACAAATCGCTAGCCCCCAATGCCAAACCCCGCTTTGATACC
ATTGTCAAAGTATTGGACGCGCTTGGCGTGCAAATCAAAATCAGCGCAAAAACCGCCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8649.65 Da        Isoelectric Point: 4.6412

>AT190653 WP_015780318.1 NZ_CP069495:c2061496-2061263 [Kytococcus sedentarius]
MTVATSVKLSDETGRKLEQLAAATGRSKSYYLREAVETHIDRLLYEYGIVQRVEDVRAGREATYGLDEVEADLGLDR

Download         Length: 234 bp

>AT190653 NZ_CP091516:1211820-1212119 [Kingella potus]
ATGAGATACATCATCGAAACAACAGCGCATTTTGACGAATGGTTTGACGGCCTGCGCGATTTGCGGGCAAAAGCCAAAGT
TATTACGCGCCTGGAACGGATTGAAGCGGGCAATCTTGGCGACCATAAAGCCATAGGCGGCGGCCTTTCCGAAATCCGCA
TAAACGAAGGCAAAGGCTACCGCCTGTATTACACCATACGCGGCAATACCGTTATTTTCATGCTGGCAGGGGGCAACAAA
TCCACCCAACAGGCCGATATTGCCCGCGCCCGCCAACTCAAAGAGGACTTGAACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References