Detailed information of TA system TA190652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1742283..1742938
• Replicon: chromosome
• Accession: NZ_CP069495
• Organism: Kytococcus sedentarius strain FDAARGOS_1200

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6J30_RS08150
• Protein ID: WP_204159413.1
• Coordinates: 1742283..1742708 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6J30_RS08155
• Protein ID: WP_110100006.1
• Coordinates: 1742705..1742938 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J30_RS08130	1738120..1738623	+	504	WP_204159409.1	flavodoxin family protein	-
I6J30_RS08135	1738730..1740505	+	1776	WP_204159410.1	AAA family ATPase	-
I6J30_RS08140	1740502..1741716	+	1215	WP_204159411.1	hypothetical protein	-
I6J30_RS08145	1741911..1742270	-	360	WP_204159412.1	GNAT family N-acetyltransferase	-
I6J30_RS08150	1742283..1742708	-	426	WP_204159413.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6J30_RS08155	1742705..1742938	-	234	WP_110100006.1	Arc family DNA-binding protein	Antitoxin
I6J30_RS08160	1743086..1744171	-	1086	WP_204159415.1	redox-regulated ATPase YchF	-
I6J30_RS08165	1744183..1745448	-	1266	WP_204159417.1	multidrug effflux MFS transporter	-
I6J30_RS08170	1745589..1746791	+	1203	WP_204161035.1	DNA recombination protein RmuC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

• Arc-like DNA binding domain (13-40)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15267.47 Da
• Isoelectric Point: 5.2123

>T190652 WP_204159413.1 NZ_CP069495:c1742708-1742283 [Kytococcus sedentarius]
VIILDTNVISEIFRPLPEPRVADWLTSLEGDVAITSVTLAELLAGLRRLPDGRRRDALTRRIDAALAPYRGGRAVLPFDD
VAADRYADVLVARERAGVPISTADAQIAAICLAHGATCATRNVKDFQHTGVELVDPWKVDA

Nucleotide

• Length: 426 bp

>T190652 NZ_CP091516:1211820-1212119 [Kingella potus]
ATGAGATACATCATCGAAACAACAGCGCATTTTGACGAATGGTTTGACGGCCTGCGCGATTTGCGGGCAAAAGCCAAAGT
TATTACGCGCCTGGAACGGATTGAAGCGGGCAATCTTGGCGACCATAAAGCCATAGGCGGCGGCCTTTCCGAAATCCGCA
TAAACGAAGGCAAAGGCTACCGCCTGTATTACACCATACGCGGCAATACCGTTATTTTCATGCTGGCAGGGGGCAACAAA
TCCACCCAACAGGCCGATATTGCCCGCGCCCGCCAACTCAAAGAGGACTTGAACCCATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8242.47 Da
• Isoelectric Point: 5.6643

>AT190652 WP_110100006.1 NZ_CP069495:c1742938-1742705 [Kytococcus sedentarius]
MSSIIVRGLDDAVKQQLAAQAKEHGRSMEAEVRAILTKAARRPHIGIALLAAAQDVGGVEELPIPVRDDVARAVDFE

Nucleotide

• Length: 234 bp

>AT190652 NZ_CP091516:1212116-1212415 [Kingella potus]
ATGACAAAAACCATCCCATTCGATCCTGCCCGCTACCTGAAAAACGAAGAGGAAATAGCCGTTTATTTGGAAGTGGCCGC
CGAAGAGGCGGCAGAGGCCGGAGACAACAGCATTTTGCTGCGAGCCATCAATACCGCCGCCAAAGCGCGGGGCATGATGG
AAATAGCCAAACAGGCGGGCGTTTCCCGCGAAAGCCTGTACAAATCGCTAGCCCCCAATGCCAAACCCCGCTTTGATACC
ATTGTCAAAGTATTGGACGCGCTTGGCGTGCAAATCAAAATCAGCGCAAAAACCGCCTAG