Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 57773..58410 Replicon chromosome
Accession NZ_CP069495
Organism Kytococcus sedentarius strain FDAARGOS_1200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6J30_RS00310 Protein ID WP_204159995.1
Coordinates 58018..58410 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6J30_RS00305 Protein ID WP_041290823.1
Coordinates 57773..58021 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J30_RS00285 53541..54785 - 1245 WP_204159992.1 cupin-like domain-containing protein -
I6J30_RS00290 54786..55145 - 360 WP_204159993.1 BatC protein -
I6J30_RS00295 55541..56863 + 1323 WP_049758591.1 replicative DNA helicase -
I6J30_RS00300 56899..57711 - 813 WP_204159994.1 fused MFS/spermidine synthase -
I6J30_RS00305 57773..58021 + 249 WP_041290823.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6J30_RS00310 58018..58410 + 393 WP_204159995.1 type II toxin-antitoxin system VapC family toxin Toxin
I6J30_RS00315 58415..58711 - 297 Protein_62 HNH endonuclease -
I6J30_RS00320 58805..59482 - 678 WP_204159996.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -
I6J30_RS00325 59532..59873 - 342 WP_204159997.1 DUF2200 domain-containing protein -
I6J30_RS00330 59909..60418 - 510 WP_204160919.1 HNH endonuclease -
I6J30_RS00335 61811..62872 - 1062 WP_204159998.1 lipoate--protein ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13783.70 Da        Isoelectric Point: 4.5112

>T190651 WP_204159995.1 NZ_CP069495:58018-58410 [Kytococcus sedentarius]
VIVDSSAIVAILLAEPERQVLLEAIQQAPKVAMTAASYLEVGMVVDGRGNPVLSRQYDALLEALGIEVVDTTAEQARVAR
AAHRDFGRGSGHPARLNFGDCLSYAAAVQDGVPLLFKGDDFIHTDVTPAL

Download         Length: 393 bp

>T190651 NZ_CP091515:346692-346865 [Snodgrassella alvi wkB2]
ATGAAAATACAAAAATTTTTAAACTTATTAATTTCTCAAGGAGTAAAAACTAAAGATGGCACTAAACACATAAAACTTTA
CTATAATGGTAAGCAATCGACTTTACCCAGACACCCCAGTAAAGAGATTCCAAAGCGGCTGGTTGAAAAAATCAAAAAGC
AGTTGGGATTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.15 Da        Isoelectric Point: 4.6158

>AT190651 WP_041290823.1 NZ_CP069495:57773-58021 [Kytococcus sedentarius]
MALTIKNDRVCDLAREAAQRSGQSQVSVIEQALERYLADHAEPVGRRVDEVLARIDASLAPGDAAAMRVELDRLYDERGL
PA

Download         Length: 249 bp

>AT190651 NZ_CP091515:346976-347458 [Snodgrassella alvi wkB2]
ATGGTTCAAATATCAGAAATGTATTCTCAAAATACAAGCTGTAAAACAGATATGTCTTACAGCGCATTAATACAAAAACA
AGCAAATTCATATGTAGTCACTTTTCGCGACTTACCAGAAGCATTAACCTGTGGAGATACGCTTGAAGAAGCACGTATTA
TGGCCGCAGATGCGTTACTTACTGCTTTAGAATTTTATTTTGAAGACCGTCGGCCAGTGCCTATACCTTCGAAAATGCAG
AAAGGTGAAGAATTGATTTCTTTACCTCCTAGTGTTACTGCAAAAGTACTTTTACTTAATGAAATGATTAAGCAAAATGT
TTCCAATGCAGAGTTAGCCAGACGTTTACTTACACGTCCTCAGGATGTTCAAAGGCTTACTAATCTTCGTCATGCAACTA
AAATTGATGCTATTAACGCTGCATTAAATCAACTAGGTAAACAACTACATATTAGTTTAATACCCATTCATCATTCAGCA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References