Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4894763..4895563 Replicon chromosome
Accession NZ_CP069488
Organism Escherichia coli strain FDAARGOS_1264

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag I6J94_RS23635 Protein ID WP_000342452.1
Coordinates 4895036..4895563 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag I6J94_RS23630 Protein ID WP_001277107.1
Coordinates 4894763..4895029 (+) Length 89 a.a.

Genomic Context


I6J94_RS23610I6J94_RS23615I6J94_RS23620I6J94_RS23625I6J94_RS23630I6J94_RS23635I6J94_RS23645I6J94_RS23650I6J94_RS23655I6J94_RS23660I6J94_RS23640
Location: 4890422..4891090 (669 bp)
Type: Others
Protein ID: WP_000617723.1
Location: 4891083..4892141 (1059 bp)
Type: Others
Protein ID: WP_001042013.1
Location: 4892386..4893240 (855 bp)
Type: Others
Protein ID: WP_000130217.1
Location: 4893511..4894614 (1104 bp)
Type: Others
Protein ID: WP_001021994.1
Location: 4894763..4895029 (267 bp)
Type: Antitoxin
Protein ID: WP_001277107.1
Location: 4895036..4895563 (528 bp)
Type: Toxin
Protein ID: WP_000342452.1
Location: 4896366..4897475 (1110 bp)
Type: Others
Protein ID: WP_001296485.1
Location: 4897523..4898449 (927 bp)
Type: Others
Protein ID: WP_001295097.1
Location: 4898446..4899723 (1278 bp)
Type: Others
Protein ID: WP_000803819.1
Location: 4899720..4900487 (768 bp)
Type: Others
Protein ID: WP_000082099.1
Location: 4895560..4895943 (384 bp)
Type: Others
Protein ID: WP_000778796.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6J94_RS236104890422..4891090+669WP_000617723.1cell division ATP-binding protein FtsE-
I6J94_RS236154891083..4892141+1059WP_001042013.1permease-like cell division protein FtsX-
I6J94_RS236204892386..4893240+855WP_000130217.1RNA polymerase sigma factor RpoH-
I6J94_RS236254893511..4894614+1104WP_001021994.1branched chain amino acid ABC transporter substrate-binding protein LivJ-
I6J94_RS236304894763..4895029+267WP_001277107.1DUF1778 domain-containing proteinAntitoxin
I6J94_RS236354895036..4895563+528WP_000342452.1GNAT family N-acetyltransferaseToxin
I6J94_RS236404895560..4895943-384WP_000778796.1aspartate 1-decarboxylase autocleavage activator PanM-
I6J94_RS236454896366..4897475+1110WP_001296485.1high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK-
I6J94_RS236504897523..4898449+927WP_001295097.1high-affinity branched-chain amino acid ABC transporter permease LivH-
I6J94_RS236554898446..4899723+1278WP_000803819.1branched chain amino acid ABC transporter permease LivM-
I6J94_RS236604899720..4900487+768WP_000082099.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(88-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T190650 WP_000342452.1 NZ_CP069488:4895036-4895563 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

>T190650 NZ_CP091515:345531-345713 [Snodgrassella alvi wkB2]
ATGCATAGCTCAAAGGTTATTAAAAGGCTGCTTGATGATGGGTGGTATGAGGTAGCCGTTAGAGGCAGCCATCATCAATT
CAAACATCCGGAAAAATCAGGTCGTGTTACCGTCCCTCACCCTAAAAAGGATTTACCACTCGGGACAGTAAAAAATATAT
TTAAACAAGCCGGTCTTAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT190650 WP_001277107.1 NZ_CP069488:4894763-4895029 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT190650 NZ_CP091515:345745-346170 [Snodgrassella alvi wkB2]
ATGTTTCTCTACATTGCTATACACAAAGATGAAAACACCGGTTACGGTGTAACAGTGCCCTCTTTACCCGGCTGCTTTTC
ATATGGTGATACTTTAGAAAAGGCTATTGAAGAATCTAAACAAGCCATCTTATTTCATATCGAGGGTTTACTTGAAGATG
GCATAGAACCTGAAACAAATCAGCCCGACCTTGCCACTCTCATTGATACCCCTGAGTATGCAGGAGCACAATGGTTTGGT
ATCGAGGTGAATATTGATCACCTAACCCTTAAACCAGAACGATTTAATGTTAGCTGGCCTAAATACCTTTTGAACAAGGT
TGATACCTACGTATCACTAACCCACGATACCCGTTCTAACTTTCTTGCTAAAGCCGCACTTGAGAGAATTAATAGTGCCA
ATCAAAACGCCGGCATAGCTAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A061K5K9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A061YQ57

References