Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
Location | 4894763..4895563 | Replicon | chromosome |
Accession | NZ_CP069488 | ||
Organism | Escherichia coli strain FDAARGOS_1264 |
Toxin (Protein)
Gene name | ataT | Uniprot ID | F4T503 |
Locus tag | I6J94_RS23635 | Protein ID | WP_000342452.1 |
Coordinates | 4895036..4895563 (+) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | ataR | Uniprot ID | F4T504 |
Locus tag | I6J94_RS23630 | Protein ID | WP_001277107.1 |
Coordinates | 4894763..4895029 (+) | Length | 89 a.a. |
Genomic Context
Location: 4890422..4891090 (669 bp)
Type: Others
Protein ID: WP_000617723.1
Type: Others
Protein ID: WP_000617723.1
Location: 4891083..4892141 (1059 bp)
Type: Others
Protein ID: WP_001042013.1
Type: Others
Protein ID: WP_001042013.1
Location: 4892386..4893240 (855 bp)
Type: Others
Protein ID: WP_000130217.1
Type: Others
Protein ID: WP_000130217.1
Location: 4893511..4894614 (1104 bp)
Type: Others
Protein ID: WP_001021994.1
Type: Others
Protein ID: WP_001021994.1
Location: 4894763..4895029 (267 bp)
Type: Antitoxin
Protein ID: WP_001277107.1
Type: Antitoxin
Protein ID: WP_001277107.1
Location: 4895036..4895563 (528 bp)
Type: Toxin
Protein ID: WP_000342452.1
Type: Toxin
Protein ID: WP_000342452.1
Location: 4896366..4897475 (1110 bp)
Type: Others
Protein ID: WP_001296485.1
Type: Others
Protein ID: WP_001296485.1
Location: 4897523..4898449 (927 bp)
Type: Others
Protein ID: WP_001295097.1
Type: Others
Protein ID: WP_001295097.1
Location: 4898446..4899723 (1278 bp)
Type: Others
Protein ID: WP_000803819.1
Type: Others
Protein ID: WP_000803819.1
Location: 4899720..4900487 (768 bp)
Type: Others
Protein ID: WP_000082099.1
Type: Others
Protein ID: WP_000082099.1
Location: 4895560..4895943 (384 bp)
Type: Others
Protein ID: WP_000778796.1
Type: Others
Protein ID: WP_000778796.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J94_RS23610 | 4890422..4891090 | + | 669 | WP_000617723.1 | cell division ATP-binding protein FtsE | - |
I6J94_RS23615 | 4891083..4892141 | + | 1059 | WP_001042013.1 | permease-like cell division protein FtsX | - |
I6J94_RS23620 | 4892386..4893240 | + | 855 | WP_000130217.1 | RNA polymerase sigma factor RpoH | - |
I6J94_RS23625 | 4893511..4894614 | + | 1104 | WP_001021994.1 | branched chain amino acid ABC transporter substrate-binding protein LivJ | - |
I6J94_RS23630 | 4894763..4895029 | + | 267 | WP_001277107.1 | DUF1778 domain-containing protein | Antitoxin |
I6J94_RS23635 | 4895036..4895563 | + | 528 | WP_000342452.1 | GNAT family N-acetyltransferase | Toxin |
I6J94_RS23640 | 4895560..4895943 | - | 384 | WP_000778796.1 | aspartate 1-decarboxylase autocleavage activator PanM | - |
I6J94_RS23645 | 4896366..4897475 | + | 1110 | WP_001296485.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
I6J94_RS23650 | 4897523..4898449 | + | 927 | WP_001295097.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
I6J94_RS23655 | 4898446..4899723 | + | 1278 | WP_000803819.1 | branched chain amino acid ABC transporter permease LivM | - |
I6J94_RS23660 | 4899720..4900487 | + | 768 | WP_000082099.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19673.57 Da Isoelectric Point: 6.6348
>T190650 WP_000342452.1 NZ_CP069488:4895036-4895563 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD
Download Length: 528 bp
>T190650 NZ_CP091515:345531-345713 [Snodgrassella alvi wkB2]
ATGCATAGCTCAAAGGTTATTAAAAGGCTGCTTGATGATGGGTGGTATGAGGTAGCCGTTAGAGGCAGCCATCATCAATT
CAAACATCCGGAAAAATCAGGTCGTGTTACCGTCCCTCACCCTAAAAAGGATTTACCACTCGGGACAGTAAAAAATATAT
TTAAACAAGCCGGTCTTAAATAA
ATGCATAGCTCAAAGGTTATTAAAAGGCTGCTTGATGATGGGTGGTATGAGGTAGCCGTTAGAGGCAGCCATCATCAATT
CAAACATCCGGAAAAATCAGGTCGTGTTACCGTCCCTCACCCTAAAAAGGATTTACCACTCGGGACAGTAAAAAATATAT
TTAAACAAGCCGGTCTTAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9929.38 Da Isoelectric Point: 10.0863
>AT190650 WP_001277107.1 NZ_CP069488:4894763-4895029 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM
Download Length: 267 bp
>AT190650 NZ_CP091515:345745-346170 [Snodgrassella alvi wkB2]
ATGTTTCTCTACATTGCTATACACAAAGATGAAAACACCGGTTACGGTGTAACAGTGCCCTCTTTACCCGGCTGCTTTTC
ATATGGTGATACTTTAGAAAAGGCTATTGAAGAATCTAAACAAGCCATCTTATTTCATATCGAGGGTTTACTTGAAGATG
GCATAGAACCTGAAACAAATCAGCCCGACCTTGCCACTCTCATTGATACCCCTGAGTATGCAGGAGCACAATGGTTTGGT
ATCGAGGTGAATATTGATCACCTAACCCTTAAACCAGAACGATTTAATGTTAGCTGGCCTAAATACCTTTTGAACAAGGT
TGATACCTACGTATCACTAACCCACGATACCCGTTCTAACTTTCTTGCTAAAGCCGCACTTGAGAGAATTAATAGTGCCA
ATCAAAACGCCGGCATAGCTAAATGA
ATGTTTCTCTACATTGCTATACACAAAGATGAAAACACCGGTTACGGTGTAACAGTGCCCTCTTTACCCGGCTGCTTTTC
ATATGGTGATACTTTAGAAAAGGCTATTGAAGAATCTAAACAAGCCATCTTATTTCATATCGAGGGTTTACTTGAAGATG
GCATAGAACCTGAAACAAATCAGCCCGACCTTGCCACTCTCATTGATACCCCTGAGTATGCAGGAGCACAATGGTTTGGT
ATCGAGGTGAATATTGATCACCTAACCCTTAAACCAGAACGATTTAATGTTAGCTGGCCTAAATACCTTTTGAACAAGGT
TGATACCTACGTATCACTAACCCACGATACCCGTTCTAACTTTCTTGCTAAAGCCGCACTTGAGAGAATTAATAGTGCCA
ATCAAAACGCCGGCATAGCTAAATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061K5K9 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YQ57 |