190647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3963855..3964450 Replicon chromosome
Accession NZ_CP069488
Organism Escherichia coli strain FDAARGOS_1264

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag I6J94_RS19375 Protein ID WP_000239579.1
Coordinates 3963855..3964205 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag I6J94_RS19380 Protein ID WP_001223208.1
Coordinates 3964199..3964450 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J94_RS19355 3959301..3960323 - 1023 WP_001296689.1 ABC transporter permease -
I6J94_RS19360 3960337..3961839 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
I6J94_RS19365 3961979..3962935 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6J94_RS19370 3963245..3963775 + 531 WP_000055075.1 inorganic diphosphatase -
I6J94_RS19375 3963855..3964205 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
I6J94_RS19380 3964199..3964450 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6J94_RS19385 3964662..3965003 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6J94_RS19390 3965006..3968785 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T190647 WP_000239579.1 NZ_CP069488:c3964205-3963855 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T190647 NZ_CP091512:1305907-1306254 [Vitreoscilla stercoraria]
ATGTGGACAGTCATCACGACAAATCTGTTTAACGAATGGCTTGATGAGCAAGATGAGTCAACTCAAGAAAAAGTTTTAGC
TGGATTGGTAGTATTACAACAGCAAGGCCCGAGTCTTGGAAGACCTTTGGTGGATACTGTATATGGTTCTAAATTCACTA
ATATGAAAGAACTACGCATTCAACATAAAGGCAAACCATTAAGAGCATTTTTTGCTTTTGATCCGCTAAGGCAAGCGATA
GTACTGTGTGTGGGCGATAAGAGCGGTAAAAAACGTTTTTATATTGAGATGATTGCCATTGCCGATGAAGAGTATGAACG
TCATCTATCAACTTTAGGAGAACATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT190647 WP_001223208.1 NZ_CP069488:c3964450-3964199 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT190647 NZ_CP091512:1306256-1306558 [Vitreoscilla stercoraria]
ATGGCTAAAACCTTAGACGAGTTATTGGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAGAAATGGCAGATGAGCT
TTTGCTAGCAAACCAACTTTATCTTATTAGAGAAGAACTAGAAATATCTCAAAAACAATTAGCAGAAGCCTTAGGCATTA
AACAACCGTCACTCTCGGCGATTGAAAATCGTGGTAATGACCTTAAAATTTCCACCATGAAAAAATATGTTGAGGCAATG
GGAGGAAAGCTTCGTATCGATGTTGAACTTCCAACCGGTAAGCATATTGGATTTAATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References