Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3864217..3865052 Replicon chromosome
Accession NZ_CP069488
Organism Escherichia coli strain FDAARGOS_1264

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag I6J94_RS18880 Protein ID WP_000854759.1
Coordinates 3864217..3864594 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag I6J94_RS18885 Protein ID WP_001295723.1
Coordinates 3864684..3865052 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J94_RS18855 3860328..3861968 - 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -
I6J94_RS18860 3862741..3862917 - 177 Protein_3692 helix-turn-helix domain-containing protein -
I6J94_RS18865 3863281..3863439 - 159 WP_001467148.1 hypothetical protein -
I6J94_RS18870 3863539..3863715 - 177 WP_000839286.1 DUF957 domain-containing protein -
I6J94_RS18875 3863732..3864220 - 489 WP_000761690.1 hypothetical protein -
I6J94_RS18880 3864217..3864594 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
I6J94_RS18885 3864684..3865052 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J94_RS18890 3865215..3865436 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6J94_RS18895 3865499..3865975 - 477 WP_001186775.1 RadC family protein -
I6J94_RS18900 3865991..3866464 - 474 WP_001350782.1 antirestriction protein -
I6J94_RS18905 3866806..3867624 - 819 WP_001234738.1 DUF945 domain-containing protein -
I6J94_RS18910 3867779..3867937 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3852571..3881832 29261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T190646 WP_000854759.1 NZ_CP069488:c3864594-3864217 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T190646 NZ_CP091510:c827395-827273 [Neisseria arctica]
ATGAAAAAACTAATTCTTATCGCCCTATCCGCCACCGCTATACTCTCTGCCTGCAACACCGTATCCGGTTTCGGCAAAGA
CGTACAAAAAGCCGGCAACACTATCGAACGCGTAGCTAACTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT190646 WP_001295723.1 NZ_CP069488:c3865052-3864684 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT190646 NZ_CP091510:c827239-827102 [Neisseria arctica]
ATGAAAAAAACTTTTTGGCTTGCCCTAGGTGCGGCCGTATTACTCAGTGCCTGCAATACCGTAGCTGGCTTCGGAGCTGA
TGTGCAAAAAGCAGGCAGCAAACTTGAGCAGTCTGCCGAACGCCACAACGCGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References