Detailed information of TA system TA190645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3831595..3832415
• Replicon: chromosome
• Accession: NZ_CP069488
• Organism: Escherichia coli strain FDAARGOS_1264

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: I6J94_RS18720
• Protein ID: WP_001054379.1
• Coordinates: 3831595..3831852 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J94_RS18725
• Protein ID: WP_000123957.1
• Coordinates: 3831864..3832415 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J94_RS18700	3827142..3828122	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6J94_RS18705	3828705..3829811	-	1107	Protein_3661	DNA helicase	-
I6J94_RS18710	3829874..3831021	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
I6J94_RS18715	3831054..3831218	+	165	Protein_3663	GNAT family N-acetyltransferase	-
I6J94_RS18720	3831595..3831852	+	258	WP_001054379.1	YjhX family toxin	Toxin
I6J94_RS18725	3831864..3832415	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
I6J94_RS18730	3832467..3833213	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
I6J94_RS18735	3833341..3833601	+	261	WP_000077645.1	hypothetical protein	-
I6J94_RS18740	3833639..3833755	+	117	Protein_3668	VOC family protein	-
I6J94_RS18745	3834000..3835121	+	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J94_RS18750	3835118..3835396	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J94_RS18755	3835408..3836721	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	3820216..3840636	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T190645 WP_001054379.1 NZ_CP069488:3831595-3831852 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190645 NZ_CP091509:c1985214-1984966 [Neisseria dumasiana]
ATGGACAATGTAGTCAGTTACACCGCTGCTCGAGAAGACTTGGCCAACATCATGACCAAAGTGTGTGATGATCATGTCGT
TACACATATTACCCGCCGCAACGGTGGCAATTGTGTTTTGATGTCGGAAGAAGAGTACAACTCAATTATGGAAACGCTTT
ATCTGTTTGGCAACCCGACCAATGCTGCCCGTTTGGAGCATTCTTTGGCTCAAGCCGAGCGTGGCGAGTTTGTGGATGTC
GAATTATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT190645 WP_000123957.1 NZ_CP069488:3831864-3832415 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190645 NZ_CP091509:c1984969-1984709 [Neisseria dumasiana]
ATGAAACACCGCTTTACCGCAGATGCAGCAGAGGACTTAGCCTACTGGGTAAAGCATGATGGAAGGAAGGTGGAACGGAT
TAAAGTTCTGTTGGAAGATATTAAAATCAACCACCCTAAAGGCATCGGTAAGCCGGAGCCACTCAGGCATCAGAAATCAG
GTTTGTGGTCGCGTAGGATAGATCGGGAACACAGACTGGTTTACTCCGTAGAAGAAGATACGGTAACAGTTTATGCTTGT
CGCTTTCACTATGGACGTTAG

Structures

Toxin

• AlphaFold DB: B6I030