Detailed information of TA system TA190642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3403313..3405002
• Replicon: chromosome
• Accession: NZ_CP069488
• Organism: Escherichia coli strain FDAARGOS_1264

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: I6J94_RS16665
• Protein ID: WP_000365807.1
• Coordinates: 3403313..3404233 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: I6J94_RS16670
• Protein ID: WP_001295795.1
• Coordinates: 3404220..3405002 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J94_RS16625	3398786..3399496	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
I6J94_RS16630	3399803..3400132	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
I6J94_RS16635	3400144..3400307	-	164	Protein_3258	tail fiber assembly protein	-
I6J94_RS16640	3400381..3400995	-	615	WP_001019923.1	YagU family protein	-
I6J94_RS16645	3401210..3401395	-	186	WP_000146240.1	hypothetical protein	-
I6J94_RS16650	3401444..3401602	+	159	Protein_3261	integrase	-
I6J94_RS16655	3401829..3402164	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
I6J94_RS16660	3402372..3403148	+	777	WP_000171155.1	site-specific integrase	-
I6J94_RS16665	3403313..3404233	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6J94_RS16670	3404220..3405002	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6J94_RS16675	3405286..3408384	+	3099	WP_000673070.1	type I restriction endonuclease subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3363097..3412065	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T190642 WP_000365807.1 NZ_CP069488:c3404233-3403313 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T190642 NZ_CP091509:1588132-1588386 [Neisseria dumasiana]
ATGAAAAAGAAACACCAAAGAACGTTTGCTTTAATATTCAACCGCCCTGTATCCGGCAGCATTAAATGGGGGGATATTGA
AGCCCTGTTTACCGAATTGGGCGCGGAAATACAAGAAAGGGAAGGTAGTCGTGTGGCCGTAATTCTTTTCGGGCAAGTGA
AAGTGTTTCATAGGCCGCATCCAAGCCCTGATACGGATAAAGGCGCGGTTGCGAGCGTGCGCAAATGGTTGGAAGAAAAC
GGAGTAAAGCCATGA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT190642 WP_001295795.1 NZ_CP069488:c3405002-3404220 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT190642 NZ_CP091509:1588383-1588718 [Neisseria dumasiana]
ATGAACAATGTAATGGAAATCAACGGCCATAAAGCCATTATTCAATACGACCCTGAAACCGAGTTGCTGCGTGGCGAGTT
TATCGGCCTCAACGGCGGGGCGGATTTTTACGCCGATAACGTGGCAGACTTGCACAAAGAGGGCGCGGCCAGTTTGGCGG
TTTTTCTCGATGTGTGCAAAGAAAAAGGCATTGAGCCGTATAAACGGTATTCAGGCCGCTTTAATGTGCGGGTAAGCCCT
GAAACCCATGCAGCCGCGGCAGCGGCGGCGGCAGCGCAAAATATCAGCCTGAATGAATGGGTCAACCGTGCAATCAGCCA
ATCCGCCCATGCCTGA

Structures

Toxin

• AlphaFold DB: A0A061KTE0