190639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2065846..2067434 Replicon chromosome
Accession NZ_CP069488
Organism Escherichia coli strain FDAARGOS_1264

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag I6J94_RS10040 Protein ID WP_001125411.1
Coordinates 2066112..2067434 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag I6J94_RS10035 Protein ID WP_001296076.1
Coordinates 2065846..2066112 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J94_RS10020 2062214..2063665 + 1452 WP_000854638.1 tagaturonate reductase -
I6J94_RS10025 2063862..2064776 + 915 WP_001296077.1 bestrophin family protein -
I6J94_RS10030 2064780..2065538 - 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
I6J94_RS10035 2065846..2066112 + 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I6J94_RS10040 2066112..2067434 + 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
I6J94_RS10045 2068383..2068751 + 369 Protein_1962 fimbrial protein -
I6J94_RS10050 2069113..2069823 + 711 WP_001195176.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T190639 WP_001125411.1 NZ_CP069488:2066112-2067434 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

>T190639 NZ_CP091507:c1783306-1783115 [Uruburuella suis]
ATGCGCAAACTGCAACAATTGAATGCCGCTGCGGATTTGAGTTTTTTGAAAATACCGCCCGGCAATCGTTTGGAAGCGTT
GAAAGACAACCGGCAGGGTCAGCACAGCATCCGCATCAATGATCAATGGCGGATTTGCTTTATCTGGGCAAACGGCCATG
CCTGCTGTGTTGAAATTGTGGATTATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT190639 WP_001296076.1 NZ_CP069488:2065846-2066112 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT190639 NZ_CP091507:c1783093-1782791 [Uruburuella suis]
ATGATGAATATGCGAGAAATACCTTTGGCCCATCCCGGCGAAATTCTGCTGGAAGATTGGCTCAAGCCGATGAATATCAG
CCAATATGCTTTGGCCAAAGCCATCGATGTGCCGCCGCGCCGTATCAACGAAATCGTGAAAGGCAAGCGCGCAATCACGG
CCGACACGGCTTTGCGGCTGGCTGCTTTTTTCAACACCGATGCGCAAAGCTGGCTGAACCTGCAAAGTCATTACGATGCA
GAAAACACACGGGTGGCGATTGCCGAGCAATTGAAGCATATCCATCCTTATCATATGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References