Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1509315..1510146 Replicon chromosome
Accession NZ_CP069488
Organism Escherichia coli strain FDAARGOS_1264

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag I6J94_RS07120 Protein ID WP_000854815.1
Coordinates 1509315..1509689 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag I6J94_RS07125 Protein ID WP_001280918.1
Coordinates 1509778..1510146 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J94_RS07080 1504711..1505877 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6J94_RS07085 1505996..1506469 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
I6J94_RS07090 1506667..1507725 + 1059 WP_001200889.1 FUSC family protein -
I6J94_RS07095 1507897..1508226 + 330 WP_000450409.1 DUF496 family protein -
I6J94_RS07100 1508327..1508509 - 183 WP_001296208.1 hypothetical protein -
I6J94_RS07105 1508563..1508709 + 147 Protein_1385 transposase domain-containing protein -
I6J94_RS07110 1508998..1509111 - 114 WP_001161660.1 DUF957 domain-containing protein -
I6J94_RS07115 1509124..1509318 - 195 WP_000988600.1 hypothetical protein -
I6J94_RS07120 1509315..1509689 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
I6J94_RS07125 1509778..1510146 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J94_RS07130 1510162..1510806 - 645 WP_000086752.1 hypothetical protein -
I6J94_RS07135 1510825..1511046 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6J94_RS07140 1511109..1511585 - 477 WP_001186200.1 RadC family protein -
I6J94_RS07145 1511601..1512074 - 474 WP_001542276.1 antirestriction protein -
I6J94_RS07150 1512168..1512413 - 246 WP_001164966.1 hypothetical protein -
I6J94_RS07155 1512413..1513231 - 819 WP_001542275.1 DUF945 domain-containing protein -
I6J94_RS07160 1513452..1513862 - 411 WP_000846703.1 hypothetical protein -
I6J94_RS07165 1513878..1514228 - 351 Protein_1397 hypothetical protein -
I6J94_RS07170 1514311..1515057 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T190628 WP_000854815.1 NZ_CP069488:c1509689-1509315 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190628 NZ_CP091496:1091758-1092243 [Enterobacter cloacae complex sp. ECL404]
GTGGGACGTGTAACCGCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGCCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAAAGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT190628 WP_001280918.1 NZ_CP069488:c1510146-1509778 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190628 NZ_CP091496:1091504-1091770 [Enterobacter cloacae complex sp. ECL404]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References