Detailed information of TA system TA190622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1843775..1844525
• Replicon: chromosome
• Accession: NZ_CP069486
• Organism: Mammaliicoccus vitulinus strain FDAARGOS_1207

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6J37_RS09350
• Protein ID: WP_016913144.1
• Coordinates: 1844388..1844525 (+)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: I6J37_RS09345
• Protein ID: WP_016913145.1
• Coordinates: 1843775..1844374 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J37_RS09320	1839634..1840395	+	762	WP_103323121.1	acetylglutamate kinase	-
I6J37_RS09325	1840718..1841845	+	1128	WP_016913149.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6J37_RS09330	1841849..1842322	+	474	WP_103323120.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6J37_RS09335	1842352..1842489	-	138	WP_016913147.1	hypothetical protein	-
I6J37_RS09340	1842576..1843727	+	1152	WP_103323119.1	N-acetylglucosamine-6-phosphate deacetylase	-
I6J37_RS09345	1843775..1844374	+	600	WP_016913145.1	hypothetical protein	Antitoxin
I6J37_RS09350	1844388..1844525	+	138	WP_016913144.1	hypothetical protein	Toxin
I6J37_RS09355	1845370..1846758	+	1389	WP_103323118.1	class II fumarate hydratase	-
I6J37_RS09360	1846847..1848373	+	1527	WP_103323117.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 5398.71 Da
• Isoelectric Point: 3.7831

>T190622 WP_016913144.1 NZ_CP069486:1844388-1844525 [Mammaliicoccus vitulinus]
MNKHPEEENEMVQDLDDVKELGKEMEQISEQNDEAYEEKKEEQDS

Nucleotide

• Length: 138 bp

>T190622 NZ_CP091492:c4161799-4161422 [Enterobacter cloacae complex sp. ECL405]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22350.23 Da
• Isoelectric Point: 4.9814

>AT190622 WP_016913145.1 NZ_CP069486:1843775-1844374 [Mammaliicoccus vitulinus]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGIHLDAENTSFFDELLDDVKKNPVNFSQIHVLDFDGKEDYYTELGV
PKKQVLKTDVGSDVESFIKDKVNTDKKKNKLMLDVITLTEDSRTGLDYNQAIHPAREVIVLVTGKEKAKAVSQLYEEPAN
GSVESAKLKQHRMVTVLLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT190622 NZ_CP091492:c4162175-4161849 [Enterobacter cloacae complex sp. ECL405]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA