190620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1075434..1076020 Replicon chromosome
Accession NZ_CP069486
Organism Mammaliicoccus vitulinus strain FDAARGOS_1207

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag I6J37_RS05425 Protein ID WP_103322579.1
Coordinates 1075688..1076020 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag I6J37_RS05420 Protein ID WP_103322578.1
Coordinates 1075434..1075694 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J37_RS05400 1071370..1072719 + 1350 WP_103322574.1 2-hydroxycarboxylate transporter family protein -
I6J37_RS05405 1072751..1073932 + 1182 WP_103322575.1 NADP-dependent malic enzyme -
I6J37_RS05410 1074022..1074741 - 720 WP_103322576.1 LysR family transcriptional regulator -
I6J37_RS05415 1074839..1075372 + 534 WP_103322577.1 DUF4865 family protein -
I6J37_RS05420 1075434..1075694 + 261 WP_103322578.1 AbrB family transcriptional regulator Antitoxin
I6J37_RS05425 1075688..1076020 + 333 WP_103322579.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J37_RS05430 1076271..1076864 + 594 WP_103322580.1 hypothetical protein -
I6J37_RS05435 1077031..1078401 - 1371 WP_103322581.1 aminopeptidase P family N-terminal domain-containing protein -
I6J37_RS05440 1078403..1079185 - 783 WP_103322582.1 DeoR/GlpR family DNA-binding transcription regulator -
I6J37_RS05445 1079351..1080763 + 1413 WP_103322583.1 PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12516.52 Da        Isoelectric Point: 8.4783

>T190620 WP_103322579.1 NZ_CP069486:1075688-1076020 [Mammaliicoccus vitulinus]
MVKQYDIIKLNLNPVQGNEKGNYRPCLVVNITEFTKQSGFAWVIPITSRKQSRYPTDVIVETEKGLINGVVDCAHIRTVD
LYTRSHQKVDVLKANKIEEVKDILTGIMDL

Download         Length: 333 bp

>T190620 NZ_CP091492:c3877284-3876874 [Enterobacter cloacae complex sp. ECL405]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.21 Da        Isoelectric Point: 5.2300

>AT190620 WP_103322578.1 NZ_CP069486:1075434-1075694 [Mammaliicoccus vitulinus]
MSEPTNKAYAKVYKSGNGQVISIKKDMLEKAGFKIGDELVMNVKGNQIVLEKPNTFKDRWRKFIEDGGEYERGEYDWGES
VGREEW

Download         Length: 261 bp

>AT190620 NZ_CP091492:c3877531-3877265 [Enterobacter cloacae complex sp. ECL405]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References